Ocular changes after simultaneous kidney-pancreas transplant
DOI: 10.32364/2311-7729-2022-22-2-132-136
I.V. Vorobyeva1, E.V. Bulava1, L.K. Moshetova1, A.V. Pinchuk2–4
1Russian Medical Academy of Continuous Professional Education, Moscow,
Russian Federation
2N.V. Sklifosovskiy Research Institute for Emergency Medical Aid, Moscow, Russian Federation
3A.I. Yevdokimov Moscow University of Medicine & Dentistry, Moscow, Russian Federation
4Research Institute of Public Health Organization and Medical Management, Moscow, Russian Federation
Type 1 diabetes (T1D) is one of the most common chronic diseases in young individuals. Diabetic nephropathy, being one of the most dangerous complications of T1D, progresses to end-stage renal disease within 10–15 years in 80%. The simultaneous kidney-pancreas transplant prevents insulin therapy and dialysis, thereby avoiding further progression of complications of diabetes. Normalization of carbohydrate metabolism and resolving of uremia after simultaneous kidney-pancreas transplant are beneficial for ocular structures. This article reviews studies on the pattern of changes in ocular structures in the post-transplant period. The procedure improves peripheral microcirculation of the bulbar conjunctiva and corneal innervation. Most studies demonstrate stabilization and improvement of the course of diabetic retinopathy as illustrated by the reduction in active vascular proliferation, need for retinal laser photocoagulation and vitrectomy. Meanwhile, some studi es failed to reveal any differences in the morphological functional status of the retina in the pre- and postoperative periods. An increase in cataract rate among simultaneous kidney-pancreas transplant recipients receiving immunosuppressant therapy remains a challenge.
Keywords: type 1 diabetes, kidney transplant, pancreas transplant, simultaneous kidney-pancreas transplant, diabetic retinopathy, diabetic macular edema.
For citation: Vorobyeva I.V., Bulava E.V., Moshetova L.K., Pinchuk A.V. Ocular changes after simultaneous kidney-pancreas transplant. Russian Journal of Clinical Ophthalmology. 2022;22(2):132–136 (in Russ.). DOI: 10.32364/2311-7729-2022-22-2-132-136.
About the authors:
Irina V. Vorobyeva — Dr. Sci. (Med.), professor of the Department of Ophthalmology, Russian Medical Academy of Continuous Professional Education; 2/1, Barrikadnaya str., Moscow, 125993, Russian Federation; ORCID iD 0000-0003-2707-8417.
Evgeniy V. Bulava — postgraduate student of the Department of Ophthalmology, Russian Medical Academy of Continuous Professional Education; 2/1, Barrikadnaya str., Moscow,
125993, Russian Federation; ORCID iD 0000-0002-7201-3885.
Larisa K. Moshetova — Dr. Sc. (Med.), Professor, Full-Member of the Russian Academy of Sciences, Honored Doctor of Russian Federation, Head of the Department of Ophthalmology. President of the Russian Medical Academy of Continuous Professional Education; Russian Medical Academy of Continuous Professional Education; 2/1, Barrikadnaya str., Moscow, 125993, Russian Federation; ORCID iD 0000-0001-5081-414X.
Aleksey V. Pinchuk — Dr. Sc. (Med.), Head of the Scientific Department of Simultaneous Kidney-Pancreas Transplant, N.V. Sklifosovskiy Research Institute for Emergency Medical Aid; 3, Bolshaya Sukharevskaya Square, Moscow, 129090, Russian Federation; associate professor of the Department of Transplantation and Artificial Organs, A.I. Yevdokimov Moscow University of Medicine & Dentistry; 20/1, Delegatskaya str., Moscow, 127473, Russian Federation; Head of the Organizational Methodical Division on Transplantation, Research Institute of Public Health Organization and Medical Management; 9, Sharikopodshipnikovskaya str., Moscow, 115088, Russian Federation; ORCID iD 0000-0001-9019-9567.
Contact information: Irina V. Vorobyeva, e-mail: irina.docent2000@mail.ru.
Financial Disclosure: no authors have a financial or property interest in any material or method mentioned.
There is no conflict of interests.
Received 01.02.2022.
Revised 25.02.2022.
Accepted 24.03.2022.
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