Ophthalmological manifestations of Peters anomaly (literature review)

O.I. Orenburkina^1,2, A.E. Babushkin³, I.R. Karachurina¹

¹Russian Center for Eye and Plastic Surgery of the Bashkir State Medical University,   Ufa, Russian Federation

²RUDN University, Moscow, Russian Federation

³Ufa Research Institute of Eye Diseases of the Bashkir State Medical University,   Ufa, Russian Federation

In addition to hereditary, more often bilateral ocular symptoms associated with clinical manifestations such as central corneal opacification (leucoma) with iridocorneal and/or corneolenticular adhesions, Peters syndrome (or Peters anomaly) also represents various systemic abnormalities. Nowadays, variety of conditions termed as Peters anomaly has been extended, and it may include both unilateral and bilateral eye disorders with or without systemic lesions. Iridocorneal and corneolenticular adhesions associated with underlying iris dysgenesis, interrupt intraocular fluid outflow and often lead to concomitant glaucoma complicating the disease course. Oftentimes, Peters anomaly is combined with other congenital visual malformations (e.g., microcornea, aniridia, polar cataract, etc.). Patients with Peters anomalies need early (up to the age of 1 year) surgical treatment (i.e., corneal grafting to restore eye media transparency and to prevent obscuration amblyopia) and anti-glaucoma interventions to reduce intraocular pressure. If mesenchymal dysgenesis and Peters anomaly are revealed, gene and systemic disorders should be identified promptly. As a result, visual acuity will depend on ocular and systemic comorbidities.

Keywords: congenital anomaly, Peters syndrome, iris dysgenesis, central corneal opacity, iridocorneal and/or corneolenticular adhesions, glaucoma, corneal grafting, anti-glaucoma interventions.

For citation: Orenburkina O.I., Babushkin A.E., Karachurina I.R. Ophthalmological manifestations of Peters anomaly (literature review). Russian Journal of Clinical Ophthalmology. 2024;24(4):–210 (in Russ.). DOI: 10.32364/2311-7729-2024-24-4-7