New model of temporary keratoprosthesis
DOI: 10.32364/2311-7729-2025-25-Suppl-18
A.D. Chuprov1,2, A.A. Gorbunov1, I.N. Dmitriev3, I.M. Yartsev3, V.A. Trubnikov1,2, D.A. Razdobreev2, Yu.A. Shcherbanova1, A.S. Maksyutov1
1Orenburg Branch of the S. Fyodorov Eye Microsurgery Federal State Institution, Orenburg, Russian Federation
2Orenburg State University, Orenburg, Russian Federation
3OOO "MIKVID", Nizhny Novgorod, Russian Federation
Aim: to develop a medical device for temporary closure of a surgical wound in the cornea during a reconstructive surgery on the eyeball and to study its physical properties.
Materials and Methods: a pilot sample of temporary keratoprosthesis is made of polycarbonate by thermal compression. The body design provided sealing of the surgical wound and reduced a risk of complications. To study the structure, optical microscopy (Olympus CKX-41 microscope) and atomic force microscopy (СMM-2000 AFM microscope) were used. The pilot sample of temporary keratoprosthesis was tested in cadaver pig eyes.
Results: polycarbonate has demonstrated excellent mechanical properties, high transparency, heat and ultraviolet resistance. The pig eye tests demonstrated reduced device insertion time and minimal trauma to eye tissue. The prosthesis provided tight fit and sealing, and high transparency provided retinal imaging. Surface examinations by optical and atomic force microscopy revealed the material homogeneity with minimal subvisible particulate matter. Surface roughness factors were in the nanometer range. The spectral measurement confirmed photostability of the material when exposed to visible light, and no destructive changes were found in the polymer chains. As the polymer retained its properties and dimensions after hours-long irradiation, this indicates its mechanical and photochemical resistance.
Conclusion: the study confirmed that, due to strength, durability and high transparency, polycarbonate is a highly efficient material for temporary keratoprosthesis. The cadaver pig eye test demonstrated tight fit, ocular cavity sealing and reduced injury rate. The identified absorption regions in the ultraviolet range do not affect real-world application of the device.
Keywords: ophthalmology, temporary keratoprosthesis, 3D modeling, thermal compression, medical device
For citation: Chuprov A.D., Gorbunov A.A., Dmitriev I.N., Yartsev I.M., Trubnikov V.A., Razdobreev D.A., Shcherbanova Yu.A., Maksyutov A.S. New model of temporary keratoprosthesis. Russian Journal of Clinical Ophthalmology. 2025;25(Special Issue):123–130 (in Russ.). DOI: 10.32364/2311-7729-2025-25-Suppl-18
About the authors:
Alexander D. Chuprov — Dr. Sc. (Med.), Professor, Director of the Orenburg Branch of the S. Fyodorov Eye Microsurgery Federal State Institution; 17, Salmyshskaya str., Orenburg, 460047, Russian Federation; Head of the Department of Biomedical Engineering, Orenburg State University; 13, Pobedy ave., Orenburg, 460018, Russian Federation; ORCID iD 0000-0001-7011-4220
Alexey A. Gorbunov — C. Sc. (Med.), Assistant Professor, Deputy Director for Medical Work of the Orenburg Branch of the S. Fyodorov Eye Microsurgery Federal State Institution; 17, Salmyshskaya str., Orenburg, 460047, Russian Federation; ORCID iD 0000-0003-3166-4419
Il'ya N. Dmitriev — Leading Engineer, OOO ''MIKVID''; 39, Gagarin ave., Nizhny Novgorod, 603009, Russian Federation; ORCID iD 0009-0006-6275-204X
Ivan M. Yartsev — Leading Engineer, OOO ''MIKVID''; room 17a, office 4, 39, Gagarin ave., Nizhny Novgorod, 603009, Russian Federation; ORCID iD 0009-0005-0726-3633
Vyacheslav A. Trubnikov — C. Sc. (Med.), Deputy Director for Innovative Development of Medical Technologies, Orenburg Branch of the S. Fyodorov Eye Microsurgery Federal State Institution; 17, Salmyshskaya str., Orenburg, 460047, Russian Federation; Senior Lecturer, Department of Biomedical Engineering, Orenburg State University; 13, Pobedy ave., Orenburg, 460018, Russian Federation; ORCID iD 0000-0002-9451-8622
Dmitryi A. Razdobreev — C. Sc. (Chem.), Assistant Professor of the Department of Biophysics and Condensed Matter Physics, Orenburg State University; 13, Pobedy ave., Orenburg, 460018, Russian Federation; ORCID iD 0000-0002-7749-0074
Yulia A. Shcherbanova — Ophthalmologist, Orenburg Branch of the S. Fyodorov Eye Microsurgery Federal State Institution; 17, Salmyshskaya str., Orenburg, 460047, Russian Federation; ORCID iD 0009-0001-4864-1988
Azamat S. Maksyutov — Ophthalmologist of Orsk Medical and Diagnostic Department of the Orenburg Branch of the S. Fyodorov Eye Microsurgery Federal State Institution; 17, Salmyshskaya str., Orenburg, 460047, Russian Federation.
Contact information: Yulia A. Shcherbanova, e-mail: nauka@ofmntk.ru
Financial Disclosure: no authors have a financial or property interest in any material or method mentioned.
There is no conflict of interest.
Received 13.12.2024.
Revised 15.01.2025.
Accepted 07.02.2025.
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