Morphofunctional characteristics of the progression of primary open-angle glaucoma
Gorshkova M.S.^1,2, Kuroyedov A.V.^2,3, Zhitareva I.V.<sup>1 

1</sup> City Clinical Hospital No.15 named after O.M. Filatov, Moscow
² Russian National Research Medical University named after N.I. Pirogov
³ Central Military Clinical Hospital named after P.V. Mandryka, Moscow

Purpose:  Determination of morphofunctional characteristics of the progression of primary open angle glaucoma (POAG) in patients with different stages of the disease using modern types of monitoring during the ongoing treatment.
Material and Methods: The study included 89 patients (153 eyes: 78 right, 75 left), 46 (51.7%) men, 43 (48.3%) women with different stages of POAG. All patients were divided into 6 (six) groups according to the stages of the disease: initial, moderate and advanced, and also by the rate of progression: stabilized and progressive, in each of the stages. The age of the patients at the time of onset of the observation ranged from 60 to 80 years and averaged 70.34 ± 0.35 years. The groups were comparable in terms of gender, age characteristics and the presence of concomitant pathology. All the  patients underwent no less than three studies on HRT 3 machines (Heidelberg Engineering, Germany) and automatic static perimeter (HFA 745i and 750i, Carl Zeiss-Meditec Inc., USA). The retrospective stage of observation was at least 3 years (an average of 5.1 (3,9; 6,4) years). 
Results and conclusions:  In the case of progression of the glaucoma process, significant changes are determined almost by all the parameters studied by us (MD, PSD, rim volume, horizontal cup / disk ratio, vertical cup / disk ratio), both according to static automatic perimetry, . The rate of progression of the glaucoma process depends on the stage of the disease, as well as on the rate of the progression. With progressive glaucoma, the rate of impairment is greater by 0.678 dB / year compared with stabilized glaucoma.

Key words: Primary open-angle glaucoma, glaucoma progression, morphometric parameters, Heidelberg retinotomography, static automatic perimetry
For citation: Gorshkova M.S., Kuroyedov A.V., Zhitareva I.V. Morphofunctional characteristics of the progression of primary open-angle glaucoma // RMJ. Clinical ophthalmology. 2017. № 2. P. 68–73.