Methods of clinical application of recombinant prourokinase in ophthalmic practice
Boiko E.V.^1,2,3, Danilichev V.F.^2,Sazhin T.G.^2, Belogurov A.A.^4, Delver E.P.^4, Agafonova O.V.^4, Suvorov A.S.<sup>2

1</sup> S. Fyodorov Eye Microsurgery Federal State Institution, St. Petersburg branch
² Military Medical Academy named after S. M. Kirov
³ North-West State Medical University named after I.I. Mechnikov, St. Petersburg
⁴ Russian Cardiology Research and Production Complex

More than 20 years ago Russian ophthalmologists together with biotechnologists developed a highly effective enzyme preparation for ophthalmology - recombinant prourokinase («Gemase»), which was created by genetic engineering method. It belongs to the fibrinolytics of the last generation and has unique properties - high specificity, low antigenicity, lack of allergenicity and minimal risk of bleeding. This allows to achieve high results in the treatment of intraocular hemorrhages and effusion of fibrin, as well as vascular occlusions, using a variety of methods of administration - forced instillations, subconjunctival, parabulbar, subtenon, anterior chamber, intravitreal and subretinal injections, as well as combined methods and electrophoresis. «Gemase» has been successfully used for many years for the treatment of fibrinoid syndrome after cataract extraction and vitreoretinal surgery, as well as for uveitis, for resolution of hyphema, traumatic and diabetic vitreous hemorrhage, for large retrogialoid and submacular hemorrhages in combination with gas injection, for inducing detachment of posterior hyaloid membranes, for enzymatic trabeculae (bleb) cleaning with glaucoma, in arterial and venous vascular occlusions. 

Keywords: enzyme therapy, fibrinolytic, Gemase, fibrin exudate, hyphema, vitreous hemorrhage, eye trauma, retinal vein occlusion, retinal artery occlusion
For citation: Boiko E.V., Danilichev V.F., Sazhin T.G. et al. Methods of clinical application of recombinant prourokinase in ophthalmic practice // RMJ. Clinical ophthalmology. 2017. № 2. P. 118–129.