Local conjunctival AL amyloidosis
DOI: 10.32364/2311-7729-2026-26-1-10
E.V. Reznik1,2, T.L. Nguyen3, Ya.V. Parmon4, S.E. Arakelov5, L.M. Mikhaleva6
1Pirogov Russian National Research Medical University, Moscow, Russian Federation
2Academician G.M. Savel'eva City Clinical Hospital No. 31, Moscow, Russian Federation
3Central Military Hospital No. 108, Hanoi, Vietnam
4Helmholtz National Medical Research Center, Moscow, Russian Federation
5V.P. Demikhov City Clinical Hospital, Moscow, Russian Federation
6Research Institute of Human Morphology named after Academician A.P. Avtsyn, Academician B.V. Petrovskiy Russian Scientific Center of Surgery, Moscow, Russian Federation
Amyloidosis is a group of diseases characterized by deposition of abnormal glycoprotein (i.e., amyloid) in tissues leading to structural changes and dysfunction of target organs. Amyloidosis can be both systemic (damage to two or more organ systems) or, less often, local (i.e. localized within a morphological unit). Amyloidosis may affect any organ. Its progression is extremely unpredictable, and the disease can result in a poor outcome. Thus, any practitioner, including an ophthalmologist, should consider the condition as a part of differential diagnosis, and ensure timely appropriate routing and therapy of a patient. Ocular amyloidosis occurs in 4% of all patients with local amyloidosis. Conjunctival amyloidosis is poorly reported, as it is very rare in clinical practice. The disease may be local without association with other systemic manifestations. The authors present a clinical case report of histologically verified amyloidosis associated with synthesis of free light chains of immunoglobulins in both eyes (first, in the right eye and, then, in the left one) without damage to other organs. The patient underwent a surgical intervention for local removal of the affected tissue and an examination to exclude a potential risk of systemic amyloidosis.
Keywords: amyloidosis, local amyloidosis, conjunctival amyloidosis, ocular amyloidosis, AL amyloidosis, systemic amyloidosis.
For citation: Reznik E.V., Nguyen T.L., Parmon Ya.V., Arakelov S.E., Mikhaleva L.M. Local conjunctival AL amyloidosis. Russian Journal of Clinical Ophthalmology. 2026;26(1):65–70 (in Russ.). DOI: 10.32364/2311-7729-2026-26-1-10
ABOUT THE AUTHORS:
Elena V. Reznik — Dr. Sc. (Med.), Assistant Professor, Head of the Department of Propaedeutics of Internal Diseases No. 2, Institute of Clinical Medicine, Pirogov Russian National Research Medical University; 1, bld. 6, Ostrovityanov str., Moscow, 117513, Russian Federation; Cardiologist, Therapist, Specialist in Functional and Ultrasound Diagnostics, Academician G.M. Savel'eva City Clinical Hospital No. 31; 42, Lobachevskyi str., Moscow, 119415, Russian Federation; ORCID iD 0000-0001-7479-418X
Nguyen Thanh Luan — C. Sc. (Med.), Interventional Cardiologist, Department of Cardiovascular Diagnostics and Intervention, Central Military Hospital No. 108; 1, Tran Hung Dao Street, Hanoi, 113000, Vietnam; ORCID iD 0000-0002-8856-4542
Yanina V. Parmon — C. Sc. (Med.), Ophthalmologist, Head of the Ophthalmological Department for Treatment of Oncological Eye Diseases, Helmholtz National Medical Research Center; 14/19, Sadovaya-Chernogryazskaya str., Moscow, 105062, Russian Federation; ORCID iD 0009-0003-1320-8134
Sergey E. Arakelov — Dr. Sc. (Med.), Oncologist, Chief Physician of V.P. Demikhov City Clinical Hospital; 1/1, Velozavodskaya str., Moscow, 115280, Russian Federation; ORCID iD 0000-0003-3911-8543
Lyudmila M. Mikhaleva — Dr. Sc. (Med.), Professor, Corresponding Member of the Russian Academy of Sciences, Vice-President of the Russian Society of Pathologists, Director of Research Institute of Human Morphology named after Academician A.P. Avtsyn, Academician B.V. Petrovskiy Russian Scientific Center of Surgery; 3, Tsyurupa str., Moscow, 117418, Russian Federation; ORCID iD 0000-0003-2052-914X
Contact information: Nguyen Thanh Luan, e-mail: truongthianh0302@gmail.com
Financial Disclosure: no authors have a financial or property interest in any material or method mentioned.
There is no conflict of interest.
Received 09.10.2024.
Revised 05.11.2024.
Accepted 28.11.2024.
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