DOI: 10.21689/2311-7729-2019-19-1-38-41

Clinical trials on carotenoids and vitamin mineral supplements in ophthalmology

A.A. Gvetadze¹, M.G. Rabadanova^1,2
1City Clinical Hospital №15, Moscow, Russian Federation
²Pirogov Russian National Research Medical University, Moscow, Russian Federation

This article reviews some of the large-scale multicentral clinical trials on lutein, zeaxanthin, and vitamins and minerals (AREDS 1, 2001; AREDS 2, 2006; LUNA, 2006; CARMA, 2006). The authors discuss etiology and pathogenesis of age-related macular degeneration (AMD) as well as the role of oxidative stress. Retinal protective effect of lutein and zeaxanthin is highlighted. Key markers of the efficacy of the preventive treatment with carotenoids were identified, i.e., increased macular pigment optical density, the presence of lutein and zeaxanthin in blood serum, and improved vision (visual acuity, contrast sensitivity etc.). Potential risks of the progression of early AMD to the advanced disease were calculated. Recent published data from these trials have systematized current information and enabled to perform meta-analysis of trials on vitamin mineral supplements.

Key words: carotenoids, nutrients, oxidative stress, vitamin mineral supplements, lutein, zeaxanthin, antioxidant, retinal protection, macular pigment optical density, age-related macular degeneration, clinical trials, meta-analysis.
For citation: Gvetadze A.A., Rabadanova M.G. Clinical trials on carotenoids and vitamin mineral supplements in ophthalmology. Russian Journal of Clinical Ophthalmology. 2019;19(1):38–41.