Innovations in laboratory diagnostics and clinics of retinal vein occlusion
Shelkovnikova T.V. 

Novokuznetsk State Institute of Continuing Medical Education, 
Kemerovo Regional Clinical Ophthalmologic Hospital

Aim: To study the features of laboratory disorders in the hemostasis system and their clinical manifestations in patients with retinal vein occlusion with the FV Leiden mutation and LA.
Patients and Methods: 150 patients (150 eyes) with retinal vein occlusion were observed. The age of the patients was 42 ± 10 years. Men - 63 persons, women -87 persons. The patients were divided into 3 groups: 1 group - 12 patients with RVO and hereditary APC-resistance (FV Leiden mutation) in combination with LA; Group 2 - 11 patients with RVO and FV Leiden mutation; Group 3 - 107 patients with RVO without LA and without FV Leiden mutations.
Results and conclusions. Laboratory studies of the hemostatic system were carried out, the clinic was studied in patients with retinal vein occlusion and the FV Leiden mutation in combination with LA. 
In patients with retinal vein occlusion and the FV Leiden mutation in combination with LA, the activity of factors V, VIII, vWF and intravascular activity of thrombocytes was increased, and the APC-resistance was reduced. LA aggravates endotheliosis in the microvasculature of the retina, in combination with the FV Leiden mutation it enhances thrombogenesis and significantly reduces the APC resistance index, it is also involved in the pathogenesis of thrombosis of the CRV and its branches, which is clinically manifested by retinal disseminated intravascular coagulation. 

Key words: system of hemostasis, APC index - resistance, FV Leiden mutation, LA, thrombinemia, retinal disseminated intravascular coagulation.
For citation: Shelkovnikova T.V. Innovations in laboratory diagnostics and clinics of retinal vein occlusion // RMJ. Clinical ophthalmology. 2017. № 2. P. 86–89.