The effectiveness of angioprotectors in diabetic retinopathy
Korotkih S.A., Knyazeva E. S., Bogachev A. E.

Ural state medical University, Ekaterinburg

In recent years, a close attention has been paid to such factors of the development and progression of diabetic microangiopathy, as an increase in capillary permeability, endothelial damage, reduced elasticity of erythrocytes, increased platelet aggregation and activation of coagulation factors (in particular, increased levels of fibrinogen). One of the drugs that positively affect the microcirculation and prevent the development of irreversible structural changes in the capillary vascular walls is calcium dobesilate.
The aim of this study is the research of clinical efficiency of Doxi-Hem for patients with type 2 diabetes.
Patients and methods. We conducted a single-center open randomized controlled study. The research included 40 patients (80 eyes) with type 2 diabetes with non-proliferative diabetic retinopathy (PDR). Patients were divided into 2 equal groups with randomization made by using random numbers method. Patients of the study group in addition to basic therapy (antihypertensive and hypoglycemic agents) took calcium dobesilate (Doxi-Hem – capsules of 500 mg), 1 capsule 3 times a day during 4 months. The study of eye functions and status, and fundus photography was made before the research (1st reference point), and after 2 months and 4 months from the beginning of the research. 
Results. After 4 months (3rd reference point) 60% of the eyes in the study group revealed a decrease in the number of hard exudates, 70% of the eyes – a reduced number of soft exudates, 50% of the eyes – a reduced number of microaneurysms and 90% - a decrease in the number of hemorrhagic foci. These data were significantly better than those in the control group.
Conclusion. Thus, the data of the research allow to recommend Doxi-Hem for a wide application for the patients with nonproliferative and preproliferative diabetic retinopathy with type 2 diabetes.

Key words: diabetes, retinopathy diabetica, angioprotectors, calcium dobesilate.
For citation: Korotkih S.A., Knyazeva E. S., Bogachev A. E. The effectiveness of angioprotectors in diabetic retinopathy // RMJ. Clinical ophthalmology. 2017. № 1. P. 45 –48.