Dynamics of morpho-functional indicators of the visual analyzer in the preventive use of oxycarotenoids
Egorov E.A.¹, Eskina E.N.^3,4, Gvetadze A.A.^1,2, Belogurova A.V.⁴, Stepanova M.A.<sup>4

1</sup> Russian National Research Medical University named after N.I. Pirogov, Moscow
² Municipal Clinical Hospital 15 named after O.M. Filatov, Moscow
³ Institute for Advanced Studies" of the Federal Medical and Biological Agency of Russia, Moscow 
⁴ Clinic of Laser Medicine "Sphere "of Professor Eskina", Moscow

The aim of the work is to determine the dynamics of morphofunctional indices during the preventive use of oxycarotenoids in primary open-angle glaucoma, the "dry" form of age-related macular degeneration and axial myopia. 
Patients and Methods. The study involved 58 patients (114eyes), 17 men and 41 women. The first group consisted of 18 patients (36 eyes), 4 men and 14 women diagnosed with primary open-angle glaucoma (POAG) of the initial stage; the second group consisted of 20 patients (38 eyes), 1 male and 19 women diagnosed with a "dry" form of age-related macular degeneration (AMD). The control group consisted of 20 healthy volunteers (40 eyes), 12 men and 8 women with no ophthalmopathology and refraction close to emmetropic. In addition to the standard ophthalmologic examination, all patients underwent echobiometry, optical coherence tomography (OCT) of the macular area, spatial contrast sensitivity (SCS), determination of the optical density of the macular pigment (ODMP), digital photography of the fundus.
Results: The analysis of baseline indicators revealed a significant decrease in the average deviation of photosensitivity (MD), as well as foveal photosensitivity. When analyzing the index of the ODMP, its decline is noted in all major groups. According to OCT in the main groups, the retina thickness (RT) in the fovea and the choroid thickness (CT) in all investigated sectors was reduced. When comparing the results of SCS measurement, there are significant changes in glaucoma. 
Analysis of the data against the background of the preventive use of oxycarotenoids showed that in the group of patients with POAG, the parameters of photosensitivity of the retina, ODMP and SCS increased, in addition, CT in the nasal sector increased slightly. In the group of patients with a "dry" form of AMD, MD and foveal photosensitivity of the retina improved, and the parameters of ODMP and SCS increased. There were no significant changes in the group in the dynamics.
Conclusion: The results of the study confirm the improvement of the morphofunctional parameters by the preventive use of oxycarotenoids in patients with a "dry" form of AMD and POAG.

Key words: primary open-angle glaucoma, age-related macular degeneration, antioxidants, lutein, oxycarotenoids, optical density of macular pigment, spatial contrast sensitivity, optical coherence tomography of the retina.
For citation: Egorov E.A., Eskina E.N., Gvetadze A.A. et al. Dynamics of morpho-functional indicators of the visual analyzer in the preventive use of oxycarotenoids // RMJ. Clinical ophthalmology. 2017. № 3. P. 155–160.