Russian Medical Inquiry
(RMZh. Meditsinskoe Obozrenie) ISSN 2587-6821 (Print), 2686-9918 (Online)

Patient management with complaints of vertigo at the first visit

VAK

Scopus

E-libraryDimensions

russian citation indexULRICHS

roaddoaj

CyberleninkaGoogle Scholar

vinitiResearch4life

MendeleyScilit

РГБWhite list




Open accessCrossrefAntiplagiat

RMJ.ru




DOI: 10.32364/2587-6821-2023-7-10-8

A.V. Amelin1, S.V. Lilenko2,3, M.V. Zamergrad4,5, A.L. Guseva6, O.V. Zaitseva7, V.A. Voronov3, D.Yu. Demidenko3, M.I. Koreshkina8, D.A. Ovchinnikov9

1I.P. Pavlov First St. Petersburg State Medical University, St. Petersburg, Russian Federation

2St. Petersburg Research Institute of Ear, Throat, Nose and Speech, St. Petersburg, Russian Federation

3I.I. Mechnikov North-Western State Medical University, St. Petersburg, Russian Federation

4Russian Medical Academy of Continuous Professional Education, Moscow, Russian Federation

5I.V. Davydovskiy City Clinical Hospital, Moscow, Russian Federation

6Pirogov Russian National Research Medical University, Moscow, Russian Federation

7National Medical Research Center of Otorhinolaryngology, Federal Research and Clinical Center of the Federal Medical Biological Agency, Moscow, Russian Federation

8Adelmed Medical Board LLC, St. Petersburg, Russian Federation

9V.A. Almazov National Medical Research Center, St. Petersburg, Russian Federation

Vertigo and balance disorders are one of the most common causes of patients seeking medical help. Vertigo and balance disorders study primarily consists of the following: complaint report, anamnestic data and neurovestibular study. Currently, an algorithm is used based on the identification of three vestibular syndromes: acute, recurrent and chronic, as well as on the analysis of vertigo triggers and concomitant symptoms. Primarily, it is important to determine which vestibular syndrome is acute, recurrent or chronic at the first patient visit with vertigo and balance disorders. Besides, using the otoneurological examination methods is essential for determining the presence or absence of signs concerning the central nervous system disorder or the labyrinth. At the same time, it should be understood that the nervous system disorders accompanied by vertigo can pose a particular danger to the patient and should be excluded first of all. For the treatment and rehabilitation of patients with vertigo, individual selection of therapy and vestibular rehabilitation programs is most effective, taking into account the origin of vestibular disorder, the progression severity, as well as the age, physical and emotional condition. Vestibular rehabilitation can significantly reduce the vertigo severity and improve resistance indicators in patients with vestibular disorders. To improve vestibular compensation, it is advisable to use drug therapy with betahistine dihydrochloride, 48 mg per day, in a modified-release dosage form for better adherence.

Keywords: dizziness, balance disorder, acute vestibular syndrome, chronic vestibular syndrome, recurrent vestibular syndrome, betahistine, neurovestibular study.

For citation: Amelin A.V., Lilenko S.V., Zamergrad M.V., Guseva A.L., Zaitseva O.V., Voronov V.A., Demidenko D.Yu., Koreshkina M.I., Ovchinnikov D.A. Patient management with complaints of vertigo at the first visit. Russian Medical Inquiry. 2023;7(10):658–665 (in Russ.). DOI: 10.32364/2587-6821-2023-7-10-8.


About the authors:

Alexander V. Amelin — Dr. Sc. (Med.), Professor of the Department of Neurology, neurologist, Head of the Department of General Neurology of the Research Institute of Neurology, Head of the Center for Diagnosis and Treatment of Cephalgia, I.P. Pavlov First St. Petersburg State Medical University; 6–8, Lev Tolstoy Str., St. Petersburg, 197022, Russian Federation; ORCID iD 0000-0001-6437-232.

Sergey V. Lilenko — Dr. Sc. (Med.), Head of the Vestibular Laboratory, St. Petersburg Research Institute of Ear, Throat, Nose and Speech; 9, Bronnitskaya Str., St. Petersburg, 190013, Russian Federation; Professor of the Department of Otorhinolaryngology, I.I. Mechnikov North-Western State Medical University; 41, Kirochnaya str., St. Petersburg, 191015, Russian Federation; ORCID iD 0000-0001-9858-5219.

Maxim V. Zamergrad — Dr. Sc. (Med.), Professor of the Department of Neurology with the Faculty of Reflexology and Manual Therapy, Russian Medical Academy of Continuous Professional Education; 2/1, Barricadnaya Str., Moscow, 125993, Russian Federation; Head of the Vertigo Center, I.V. Davydovskiy City Clinical Hospital; 11, Yauzskaya Str., Moscow, 109240, Russian Federation; ORCID iD 0000-0002-0193-2243.

Alexandra L. Guseva — Dr. Sc. (Med.), Associate Professor of the Department of Otorhinolaryngology of the Medical Faculty, Pirogov Russian National Research Medical University; 1, Ostrovityanov Str., Moscow, 117997, Russian Federation, ORCID iD 0000-0002-7988-4229.

Olga V. Zaitseva — C. Sc. (Med.), Head of the Research and Clinical Department of Vestibulology and Otoneurology, National Medical Research Center of Otorhinolaryngology, Federal Research and Clinical Center of the Federal Medical Biological Agency; 30, bldn. 2, Volokolamskoe road, Moscow, 123182, Russian Federation; ORCID iD 0000-0002-4975-1310.

Viktor A. Voronov — C. Sc. (Med.), Associate Professor of the Department of Otorhinolaryngology, I.I. Mechnikov North-Western State Medical University; 41, Kirochnaya str., St. Petersburg, 191015, Russian Federation; ORCID iD 0000-0002-3859-6298.

Diana Yu. Demidenko — C. Sc. (Med.), Associate Professor of the Department of Otorhinolaryngology, I.I. Mechnikov North-Western State Medical University; 41, Kirochnaya str., St. Petersburg, 191015, Russian Federation; ORCID iD 0000-0003-4604-5039.

Marina I. Koreshkina — Dr. Sc. (Med.), Head of the Cephalgia Therapy Center, Adelmed Medical Board LLC; 1, Michurinskaya Str., St. Petersburg, 197046, Russian Federation; ORCID iD 0000-0002-4908-1193.

Dmitry A. Ovchinnikov — neurologist, Chief Medical Officer of the University Clinic, V.A. Almazov National Medical Research Center; 2, Akkuratov Str., St. Petersburg, 197341, Russian Federation; ORCID iD 0000-0001-9430-7561.

Contact information: Maxim V. Zamergrad, e-mail: zamergrad@gmail.com.

Financial Disclosure: no authors have a financial or property interest in any material or method mentioned.

There is no conflict of interest.

Received 01.08.2023.

Revised 22.08.2023

Accepted 12.09.2023.

References
1. Lawson J., Fitzgerald J., Birchall J. et al. Diagnosis of geriatric patients with severe dizziness. J Am Geriatr Soc. 1999;47(1):12–17. DOI: 10.1111/j.1532-5415.1999.tb01895.x.
2. Jönsson R., Sixt E., Landahl S., Rosenhall U. Prevalence of dizziness and vertigo in an urban elderly population. J Vestib Res. 2004;14(1):47–52. PMID: 15156096.
3. Головокружение. Под ред. Дикса М.Р., Худа Дж.Д. Пер. с англ. Безденежных Б.Н. М.: Медицина; 1987. [Dizziness. Dix M.R., Hood J.D., eds. Translation from English Beznadezhnikh B.N. М.: Medicine; 1987 (in Russ.)].
4. Бронштейн А., Лемперт Т. Головокружение. Пер. с англ. Гузь Е.В. Под ред. Парфенова В.А. М.: ГЭОТАР-Медиа; 2010. [Bronstein A., Lempert T. Dizziness. Translation from English Guz E.V. Parfenov V.A., ed. M.: GEOTAR-Media; 2010 (in Russ.)].
5. Лиленко С.В., Янов Ю.К., Ситников В.П. Расстройства равновесия. Часть I: Этиопатогенез и диагностика. СПб: РИА-МИА; 2005. [Lilenko S.V., Yanov Y.K., Sitnikov V.P. Balance disorders. Part I: Etiopathogenesis and diagnosis. SPb.: RIA-MIA; 2005 (in Russ.)].
6. Eggers S.D.Z., Bisdorff A., von Brevern M. et al. Classification of vestibular signs and examination techniques: Nystagmus and nystagmus-like movements. J Vestib Res. 2019;29(2-3):57–87. DOI: 10.3233/VES-190658.
7. Лиленко С.В., Аникин И.А., Хамгушкеева Н.Н. Острая периферическая вестибулярная дисфункция: диагностическая и лечебная тактика. Медицинский совет. 2020;6:114–121. DOI: 10.21518/2079-701X-2020-6-114-121. [Lilenko S.V., Anikin I.A., Khamgushkeeva N.N. Acute peripheral vestibular dysfunction: diagnostics and treatment. Medical Council. 2020;6:114–121 (in Russ.)]. DOI: 10.21518/2079-701X-2020-6-114-121.
8. Kattah J.C., Talkad A.V., Wang D.Z. et al. HINTS to diagnose stroke in the acute vestibular syndrome: three-step bedside oculomotor examination more sensitive than early MRI diffusion-weighted imaging. Stroke. 2009;40(11):3504–3510. DOI: 10.1161/STROKEAHA.109.551234.
9. Carmona S., Martínez C., Zalazar G. et al. The Diagnostic Accuracy of Truncal Ataxia and HINTS as Cardinal Signs for Acute Vestibular Syndrome. Front Neurol. 2016;7:125. DOI: 10.3389/fneur.2016.00125.
10. Vanni S., Pecci R., Edlow J.A. et al. Differential Diagnosis of Vertigo in the Emergency Department: A Prospective Validation Study of the STANDING Algorithm. Front Neurol. 2017;8:590. DOI: 10.3389/fneur.2017.00590.
11. Vanni S., Nazerian P., Casati C. et al. Can emergency physicians accurately and reliably assess acute vertigo in the emergency department? Emerg Med Australas. 2015;27(2):126–131. DOI: 10.1111/1742-6723.12372.
12. Кудрявцева А.С., Амелин А.В., Лиленко С.В., Скоромец А.А. Дифференциальная диагностика рецидивирующих эпизодов головокружения. Журнал неврологии и психиатрии им. С.С. Корсакова. 2016;116(4):4–9. DOI: 10.17116/ jnevro2016116414-9. [Kudriavtseva A.S., Amelin A.V., Lilenko S.V., Skoromets A.A. The differential diagnosis of recurrent episodes of vertigo. Zhurnal Nevrologii i Psikhiatrii imeni S.S. Korsakova. 2016;116(4):4–9 (in Russ.)]. DOI: 10.17116/jnevro2016116414-9.
13. Лиленко С.В., Сугарова С.Б., Лиленко А.С., Костевич И.В. Скрининг-тестирование и компьютеризированная вестибулометрия при вестибулярном нейроните. Медицинский совет. 2023;6:104–111. DOI: 10.21518/ms2022-007. [Lilenko S.V., Sugarova S.B., Lilenko A.S., Kostevich I.V. Screening testing and computerized vestibulometry in vestibular neuronitis. Medical Council. 2023;6:104–111 (in Russ.)]. DOI: 10.21518/ms2022-007.
14. Peppard S.B. Effect of drug therapy on compensation from vestibular injury. Laryngoscope. 1986;96(8):878–898. DOI: 10.1002/lary.1986.96.8.878.
15. Cesarani A., Alpini D., Monti B. et al. The treatment of acute vertigo. Neurol Sci. 2004;25 Suppl 1:S26–S30. DOI: 10.1007/s10072-004-0213-8.
16. Lacour M., Helmchen C., Vidal P.P. Vestibular compensation: the neuro-otologist's best friend. J Neurol. 2016;263 Suppl 1:S54–S64. DOI: 10.1007/s00415-015-7903-4.
17. Ariyasu L., Byl F.M., Sprague M.S., Adour K.K. The beneficial effect of methylprednisolone in acute vestibular vertigo. Arch Otolaryngol Head Neck Surg. 1990;116(6):700–703. DOI: 10.1001/archotol.1990.01870060058010.
18. Shupak A., Issa A., Golz A. et al. Prednisone treatment for vestibular neuritis. Otol Neurotol. 2008;29(3):368–374. DOI: 10.1097/MAO.0b013e3181692804.
19. Пальчун В.Т., Гусева А.Л., Байбакова Е.В., Макоева А.А. Особенности восстановления вестибулоокулярного рефлекса при различной степени его поражения у пациентов с вестибулярным нейронитом. Вестник оториноларингологии. 2019;84(6):33–37. DOI: 10.17116/otorino20198406133. [Pal'chun V.T., Guseva A.L., Baybakova E.V., Makoeva A.A. Recovery of vestibulo-ocular reflex in vestibular neuronitis depending on severity of vestibulo-ocular reflex damage. Vestnik Oto-Rino-Laringologii. 2019;84(6):33–37 (in Russ.)]. DOI: 10.17116/otorino20198406133.
20. Пальчун В.Т., Гусева А.Л., Чистов С.Д. Вестибулярная реабилитация: обоснование, показания, применение. Consilium Medicum. 2015;17(9):113–120. DOI: 10.26442/2075-1753_2015.9.113-120. [Palchun V.T., Guseva A.L., Chistov S.D. Vestibular rehabilitation: substantiation, indications, application. Consilium Medicum. 2015;17(9):113–120 (in Russ.)]. DOI: 10.26442/2075-1753_2015.9.113-120.
21. Hall C.D., Herdman S.J., Whitney S.L. et al. Vestibular Rehabilitation for Peripheral Vestibular Hypofunction: An Updated Clinical Practice Guideline From the Academy of Neurologic Physical Therapy of the American Physical Therapy Association. J Neurol Phys Ther. 2022;46(2):118–177. DOI: 10.1097/NPT.0000000000000382.
22. Van de Heyning P., Betka J., Chovanec M. et al. Efficacy and Safety of Intranasal Betahistine in the Treatment of Surgery-Induced Acute Vestibular Syndrome: A Double-Blind, Randomized, Placebo-Controlled Phase 2 Study. Otol Neurotol. 2023;44(5):493–501. DOI: 10.1097/MAO.0000000000003856.
23. Scholtz A.W., Steindl R., Burchardi N. et al. Comparison of the therapeutic efficacy of a fixed lowdose combination of cinnarizine and dimenhydrinate with betahistine in vestibular neuritis: a randomized, double-blind, non-inferiority study. Clin Drug Investig. 2012;32(6):387–399. DOI: 10.2165/11632410-000000000-00000.
24. Lacour M. Betahistine treatment in managing vertigo and improving vestibular compensation: clarification. J Vestib Res. 2013;23(3):139–151. DOI: 10.3233/VES-130496.
25. Живолупов С.А., Самарцев И.Н., Сыроежкин Ф.А. Современная концепция нейропластичности (теоретические аспекты и практическая значимость). Журнал неврологии и психиатрии им. С.С. Корсакова. 2013;113(10):102–108. [Zhivolupov C.A., Samartsev I.N., Syroezhkin F.A. Contemporary conception of neuroplasticity (theoretical aspects and practical significance). Zhurnal Nevrologii i Psikhiatrii imeni S.S. Korsakova. 2013;113(10):102–108 (in Russ.)].
26. Lacour M., Sterkers O. Histamine and betahistine in the treatment of vertigo: elucidation of mechanisms of action. CNS Drugs. 2001;15(11):853–870. DOI: 10.2165/00023210-200115110-00004.
27. Ramos Alcocer R., Ledezma Rodríguez J.G., Navas Romero A. et al. Use of betahistine in the treatment of peripheral vertigo. Acta Otolaryngol. 2015;135(12):1205–1211. DOI: 10.3109/00016489.2015.1072873.
28. Замерград М.В., Морозова С.В. Современные подходы к медикаментозному лечению вестибулярного головокружения. Неврология, нейропсихиатрия, психосоматика. 2021;13(1):101–106. DOI: 10.14412/2074-2711-2021-1-101-106. [Zamergrad M.V., Morozova S.V. Modern approaches to drug treatment for vestibular vertigo. Nevrologiya, neiropsikhiatriya, psikhosomatika. 2021;13(1):101–106 (in Russ.)]. DOI: 10.14412/2074-2711-2021-1-101-106.
29. Парфенов В.А., Замерград М.В., Казей Д.В., Наута Й. Исследование эффективности и безопасности новой формы бетагистина с модифицированным высвобождением в лечении вестибулярного головокружения и болезни Меньера. Журнал неврологии и психиатрии им. С.С. Корсакова. 2020;120(12):42–48 (in Russ.)]. DOI: 10.17116/jnevro202012012142. [Parfenov V.A., Zamergrad M.V., Kazei D.V., Nauta J. A study of the efficacy and safety of a new modified-release betahistine formulation in the treatment of vestibular vertigo and Meniere's disease. Zhurnal Nevrologii i Psikhiatrii imeni S.S. Korsakova. 2020;120(12):42–48 (in Russ.)]. DOI: 10.17116/jnevro202012012142.
30. Huang T.C., Wang S.J., Kheradmand A. Vestibular migraine: An update on current understanding and future directions. Cephalalgia. 2020;40(1):107–121. DOI: 10.1177/0333102419869317.
31. Lempert T., Olesen J., Furman J. et al. Vestibular migraine: Diagnostic criteria1. J Vestib Res. 2022;32(1):1–6. DOI: 10.3233/VES-201644.
32. Headache Classification Committee of the International Headache Society (IHS). The International Classification of Headache Disorders, 3rd ed. Cephalalgia. 2018;38(1):1–211. DOI: 10.1177/0333102417738202.
33. Cohen H.S. Side-lying as an alternative to the Dix-Hallpike test of posterior canal. Otol Neurotol. 2004;25(2):130–134. DOI: 10.1097/00129492-200403000-00008.
34. Гусева А.Л. Лечебно-диагностический алгоритм при отолитиазе: дис. … д-ра мед. наук. М., 2023. [Guseva A.L. Treatment and diagnostic algorithm for otolithiasis: thesis. М., 2023 (in Russ.)].
35. Hong X., Christ-Franco M., Moher D. et al. Vitamin D Supplementation for Benign Paroxysmal Positional Vertigo: A Systematic Review. Otol Neurotol. 2022;43(7):e704–e711. DOI: 10.1097/MAO.0000000000003586.
36. Singh G., Aggarwal A., Sahni D. et al. Comparative Effectiveness Research: Betahistine add-on Therapy with Epley's Manoeuvre Versus Epley's Manoeuvre Alone in Treating Posterior BPPV Patients. Indian J Otolaryngol Head Neck Surg. 2023;75(Suppl 1):204–209. DOI: 10.1007/s12070-022-03369-7.
37. Smyth D., Britton Z., Murdin L. et al. Vestibular migraine treatment: a comprehensive practical review. Brain. 2022;145(11):3741–3754. DOI: 10.1093/brain/awac264.

License Creative Commons
This work is licensed under a Creative Commons «Attribution» 4.0 License.


Previous article
Next article