Nonsteroidal anti-inflammatory drugs in musculoskeletal pains: benefits fr om transdermal therapeutic systems

N.V. Shestakov¹, N.V. Pyatigorskaya²

¹Moscow Endocrine Plant

²Sechenov University, Moscow

The presented article highlights current medicine urgent issues, such as musculoskeletal pain and anesthesia principles. Much attention is paid to nonsteroidal anti-inflammatory drugs (NSAIDs), which have held a firm place in medical practice. Directions in the symptomatic and pathogenetic pain elimination with the use of agents that block inflammatory mediators production are considered. Side effects during the NSAIDs application are highlighted in detail, especially as the long-term administration. The article also describes the developing complication risks that lim it the therapeutic potential of such drugs, depending on their administration method. According to given data, in local NSAIDs administration, the likelihood of the adverse events decreases, and an adhesive form has many undeniable benefits and advantages.
An overview of drugs manufactured in  the transdermal therapeutic system form containing NSAIDs is presented. Nociceptive pain treatment is quite amenable to NSAIDs therapy and is safer with the transdermal therapeutic systems application. The authors conclude that it is necessary to further develop transdermal therapeutic systems with NSAIDs of domestic production.

Keywords: nonsteroidal anti-inflammatory drugs, patches with NSAIDs, musculoskeletal pain, anesthesia.

For citation: Shestakov N.V., Pyatigorskaya N.V. Nonsteroidal anti-inflammatory drugs in musculoskeletal pains: benefits from transdermal therapeutic systems. RMJ. 2019;4:28–31.