Chronic pain: from pathogenesis to innovative treatment
Rachin A.P.¹, Sharov M.N.², Averchenkova A.A.¹, Vygovskaya S.N.¹, Nuvakhova M.B.<sup>1

1</sup> «Russian Scientific Center of Medical Rehabilitation and Balneology», Moscow
² Moscow State Medical-Stomatological University named after А.I. Evdokimov

Chronic pain is one of the major medical and socio-economic problems in the world. The effectiveness of therapy of patients with chronic pain syndrome is insufficient, despite the increase in the number of analgesic drugs, physiotherapeutic and psychotherapeutic treatments. It is impossible to develop an optimal treatment of chronic pain syndromes without knowledge of the pathophysiological mechanisms. The article considers the importance of diagnosing pain syndrome in terms of specific causes of chronic back pain, as well as determining the pain source. Such identification, in turn, is based on clinical manifestations and analysis of their relationship with various pathophysiological mechanisms. The therapeutic effect on pathophysiological mechanisms is carried out by pathogenetically validated drugs and additional recommendation of food supplement Keltikan® complex. Keltikan® complex enhances the regeneration of the nervous tissue, normalizes the processes of carrying out the nerve impulse, significantly reduces the severity of the pain syndrome in patients with peripheral neuropathies. The article considers the risk factors of lumbar pain syndrome, in the pathogenesis of which the myogenic, vascular, neurogenic and other mechanisms are closely interconnected.

Key words: chronic back pain, nucleotides, Keltikan® complex.
For citation: Rachin A.P., Sharov M.N., Averchenkova A.A. et al. Chronic pain: from pathogenesis to innovative treatment // RMJ. 2017. № 9. P. 625–631.