Immunotropic drugs and adaptogens

T.P. Markova

Federal Research Clinical Center of the Russian Medical Biological Agency, Moscow

Immunotropic drugs are medications which affect immune system (e.g., stimulate synthesis of immunoglobulins, cytokines etc.). This class includes bacteria- and plant-derived medicines, bee products, hormones, cytokines, mediators etc. Adaptogens are drugs which improve the resistance to various chemical, physical, and biological effects. Adaptogens (which include ginseng, Siberian ginseng, magnolia vine and other plant-derived medicines) stimulate antioxidant protection, reduce metabolic acidosis, prevent accumulation of oxidation products, improve tissue and organ hemodynamics. Mechanisms of action of most adaptogens including their effects on immune parameters still remain elusive. Adaptogens with immunomodulating properties are of special interest. Among these agents, Trekrezan^® is a well-studied drug which provides antioxidant, reparative, anti-inflammatory, antitoxic, and energy-stabilizing (anti-asthenic) effects. Trekrezan^® is a low-toxicity drug. Its efficacy was demonstrated in various preclinical and clinical trials. Further studies on Trekrezan^® from the viewpoint of evidence-based medicine will elucidate its mechanisms of action in various immune disorders.

Keywords: immunity, cytokines, immunomodulators, bacterial lysates, adaptogens, antioxidants, Trekrezan.

For citation: Markova T.P. Immunotropic drugs and adaptogens. RMJ. 2019;8(I):60–64.