Modern possibilities of systemic enzyme therapy in the complex treatment of inflammatory processes, post-injury and post-surgery rehabilitation. Resolution of the interdisciplinary Council of Experts

Modern possibilities of systemic enzyme therapy in the complex treatment of inflammatory processes, post-injury and post-surgery rehabilitation. Resolution of the interdisciplinary Council of Experts

I.A. Apolikhina^1,2, I.G. Arsenyev³, V.G. Atrushkevich⁴, D.S. Ershov^5,6, A.V. Zaitsev⁴, E.F. Kira^7,8, S.V. Kotov^5,6,9, S.V. Minaev¹⁰, Z.G. Ordzhonikidze¹¹, D.Yu. Pushkar^4,12, E.I. Seliverstov⁵, N.S. Khodzhaev¹³, L.A. Khodyreva¹⁴, A.A. Khryanin¹⁵, I.G. Chulovskaya^5,16, E.V. Shikh²

¹V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology and Perinatology, Moscow

²I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow

³N.N. Priorov National Medical Research Center for Trauma and Orthopedics, Moscow

⁴Russian University of Medicine, Moscow

⁵Pirogov Russian National Research Medical University, Moscow

⁶N.I. Pirogov City Clinical Hospital No. 1, Moscow

⁷Russian Association for Genital Infections and Neoplasia (RAGIN), Moscow

⁸Medical Academy of MEDSI Group JSC, Moscow

⁹Moscow Multidisciplinary Clinical Center "Kommunarka", Moscow

¹⁰Stavropol State Medical University, Stavropol

¹¹S.I. Spasokukotsky Moscow Centre for Research and Practice in Medical Rehabilitation, Restorative and Sports Medicine of Moscow Healthcare Department, Moscow

¹²Botkin Hospital, Moscow

¹³S. Fyodorov Eye Microsurgery Federal State Institution, Moscow

¹⁴Research Institute of Public Health Organization and Medical Management, Moscow

¹⁵Novosibirsk State Medical University, Novosibirsk

¹⁶Russian Clinical and Research Center of Gerontology, Pirogov Russian National Research Medical University, Moscow

Despite the wide variety of alteration agents, the core of the host’s defensive response consistently comprises an infectious or aseptic inflammatory process. The principal causes of classical inflammation include a significant topical immune response to infectious agents, autoantigens, allergens, and tissue necrosis. Given that inflammation is not a binary mechanism and is regulated by numerous endogenous and exogenous factors, it remains challenging to accurately determine whether particular pharmacological agents exert a positive or negative influence on patient recovery.

Considering the complexity of injurious factors and the current limitations of conventional treatment tactics, the search for and evaluation of adjunctive therapeutic agents remains a relevant issue. On April 12, 2025, an interdisciplinary Council of Experts was held in Moscow, focusing on the use of systemic enzyme therapy following trauma and surgery, as well as in acute and chronic inflammatory conditions. It was demonstrated that the use of systemic enzyme therapy may improve overall treatment outcomes and reduce the need for additional medical interventions in patients.

Keywords: systemic enzyme therapy, anti-inflammatory agents, postoperative complications, antibacterial therapy, bacterial biofilms, adhesions, inflammation, rehabilitation, trauma.

For citation: Apolikhina I.A., Arsenyev I.G., Atrushkevich V.G., Ershov D.S., Zaitsev A.V., Kira E.F., Kotov S.V., Minaev S.V., Ordzhonikidze Z.G., Pushkar D.Yu., Seliverstov E.I., Khodzhaev N.S., Khodyreva L.A., Khryanin A.A., Chulovskaya I.G., Shikh E.V. Modern possibilities of systemic enzyme therapy in the complex treatment of inflammatory processes, post-injury and post-surgery rehabilitation. Resolution of the interdisciplinary Council of Experts. RMJ. 2025;10:65–74. DOI: 10.32364/2225-2282-2025-10-10