Possibilities of reducing the risks of polypragmasy by medical decision support systems

Yu.A. Dolgusheva^1,2, Yu.E. Efremova¹, Yu.P. Titov², P.M. Ivanova², V.G. Kudrina^2.3

¹Acad. E.I. Chazov National Medical Research Center of Cardiology, Moscow

²G.V. Plekhanov Russian University of Economics, Moscow

³Russian Medical Academy of Continuous Professional Education, Moscow

Considering a current trend towards a decrease in mortality and an increase in life expectancy, an increase in a number of polymorbid elderly persons who need to receive multiple medicines is expected. Optimized pharmacotherapy is an important and necessary therapeutic component due to relatively common potentially non-recommended drugs leading to serious adverse drug reactions (SADRs). Especially in polymorbid elderly patients, pharmacotherapy should include drug audits to identify potentially non-recommended drugs and drug-drug interactions. Medical decision support systems are being extensively implemented to improve drug prescription quality and to increase safety of drug therapy. Actually, literature data generally demonstrate positive trends in the system efficacy in the context of drug therapy management in patients with unjustified polypharmacy. However, development of the area is limited.

Keywords: medical decision support system, polypharmacy, polypragmasy, clinical guidelines, cardiovascular diseases, elderly patients, restrictive lists.

For citation: Dolgusheva Yu.A., Efremova Yu.E., Titov Yu.P., Ivanova P.M., Kudrina V.G. Possibilities of reducing the risks of polypragmasy by medical decision support systems. RMJ. 2025;8:50–54. DOI: 10.32364/2225-2282-2025-8-9