The advantages of long-acting diuretics in congestive heart failure
D.O. Dragunov, A.V. Sokolova, A.G. Arutyunov, A.S. Simbirtseva, M.S. Kurmanov

N.I. Pirogov Russian National Research Medical University, Moscow, Russia

Currently, a wide range of drugs are available in Russia. In this context, the key issue for an internist is to choose safe and effective diuretic therapy. The most commonly used diuretics excrete sodium, i.e., these drugs inhibit sodium reabsorption in the renal tubules thus leading to passive water excretion. Loop diuretics with short half-life provoke spike-like sodium diuresis followed by significant post-dose sodium retention. Spike-like sodium diuresis results in acute tubule damage caused by excess sodium. In rapid and excessive sodium excretion, this damage is irreversible. According to multiple studies, torasemide SR/Britomar is characterized by lower absorption rate and, therefore, longer half-life. The drug provides more effective and constant sodium diuresis thus reducing the risk of renal tubule damage. The absence of rebound sodium retention tends to decrease central blood pressure, augmentation index, and aortic pulse wave velocity which are considered to be independent markers of cardiovascular risk and death.

Key words: sodium, diuretics, torasemide SR, sodium diuresis.

For citation: Dragunov D.O., Sokolova A.V., Arutyunov A.G., et al. The advantages of long-acting diuretics in congestive heart failure // RMJ. Cardiology. 2016. № 9. P. –559.