Non-alcoholic fatty liver disease and probability of development of heart rate diseases
Akhmedov V.A. 

Omsk State Medical University

The review presents modern information on the possibility of the formation of rhythm disturbances, such as atrial fibrillation, prolongation of the QTc interval, ventricular arrhythmias and HBB in patients with non-alcoholic fatty liver disease. The article shows a world-wide prevalence of obesity and non-alcoholic fatty liver disease. Possible pathogenetic mechanisms of the formation of cardiac arrhythmias in patients with non-alcoholic fatty liver disease are considered. The article describes possible involvement of a number of factors associated with the metabolic syndrome, such as C reactive protein, tumor necrosis factor alpha, interleukin-6, transforming growth factor beta, endothelin -1 in the formation of ultrastructural changes in cardiomyocytes, increase in fibroblasts differentiation and myocardium fibrosis, which serves as a risk factor for the formation of cardiac arrhythmias. There is a connection between the thickness of epicardial fat layer and the progression of insulin resistance, increased risk of cardiac accidents and nonalcoholic fatty liver disease. It is shown that in patients with type 2 diabetes mellitus, the mechanisms of cardiac arrhythmias are similar to those in patients with nonalcoholic fatty liver disease without diabetes mellitus, and even factors associated with diabetes mellitus did not have such a significant influence on the occurrence of cardiac rhythm disturbances.

Key words: non-alcoholic fatty liver disease, heart rhythm disturbances, atrial fibrillation, QTc interval elongation, ventricular arrhythmias.
For citation: Akhmedov V.A. Non-alcoholic fatty liver disease and probability of development of heart rate diseases // RMJ. 2017. № 20. P. 1486–1488.