The use of complex drugs in the treatment of vascular disorders of various origins
DOI: 10.32364/2587-6821-2022-6-8-443-450
E.Yu. Solovyova1, Sh.P. Abdullaev2
1Pirogov Russian National Research Medical University, Moscow, Russian Federation
2Russian Medical Academy of Continuous Professional Education, Moscow, Russian Federation
One of the most important places in the pathogenetic therapy of various vascular disorders is occupied by angioprotective, venotonic, antiplatelet, and antithrombotic therapy. In this regard, drugs with a complex effect on various links of vascular disorders are of particular interest. These drugs include AngioNorm®. It is a dry extract obtained from a mixture of medicinal plant raw materials: horse chestnut seeds, licorice roots, hawthorn and rosehip fruits. The combined composition characteristics of the drug extract determine a wide range of its pharmacological activity. The pharmacological properties of the drug, determined by the extract composition, have been confirmed in experimental preclinical and clinical studies which have demonstrated good efficacy, safety and tolerability of therapy in patients with various vascular and microcirculatory disorders (eg. chronic venous insufficiency, hypertension, coronary heart disease, cerebrovascular disease, hemorrhoids, trophic ulcers in the setting of varicose veins, post-infarction conditions, upper limb lymphoedema). The results of clinical studies indicate the possibility of long-term and safe use of this drug in the complex therapy of various vascular lesions in outpatient and inpatient setti ngs.
Keywords: chronic venous diseases, cardiovascular diseases, microcirculation disorders, angioprotectors, antiplatelet agents, Angionorm.
For citation: Solovyova E.Yu., Abdullaev Sh.P. The use of complex drugs in the treatment of vascular disorders of various origins. Russian Medical Inquiry. 2022;6(8):443–450 (in Russ.). DOI: 10.32364/2587-6821-2022-6-8-443-450.
About the authors:
Ella Yu. Solovieva — Dr. Sc. (Med.), Associate Professor, Head of the Department of Neurology, Pirogov Russian National Research Medical University; 1, Ostrovityanov str., Moscow, 117437, Russian Federation; ORCID iD 0000-0003-1256-2695.
Sherzod P. Abdullaev — C. Sc. (Bio.), Researcher at the Research Institute of Molecular and Personalized Medicine, Russian Medical Academy of Continuous Professional Education; 2/1, Barrikadnaya str., Moscow, 125993, Russian Federation; ORCID iD 0000-0001-9001-1499.
Contact information: Sherzod P. Abdullaev, e-mail: sherzodx5@gmail.com.
Financial Disclosure: no authors have a financial or property interest in any material or method mentioned.
There is no conflict of interests.
Received 19.04.2022.
Revised 18.05.2022.
Accepted 10.06.2022.
2. Seliverstov E.I., Avak’yants I.P., Nikishkov A.S., Zolotukhin I.A. Epidemiology of Chronic Venous Disease. Flebologiya. 2016;10(1):35–43 (in Russ.). DOI: 10.17116/flebo201610135-42.
3. Kirienko A.I., Bogachev V.Y., Gavrilov S.G. et al. Chronic diseases of lower limb veins in Moscow industrial enterprises employees (results of epidemiological study). Angiologia i sosudistaya khirurgia. 2004;10(1):77–86 (in Russ.).
4. Zolotukhin I.A., Seliverstov E.I., Shevtsov Yu.N. et al. Prevalence of Chronic Venous Disease: Results of Population Based Epidemiological Study. Flebologiya. 2016;10(3):119–125 (in Russ.). DOI: 10.17116/flebo2016103119-125.
5. Matic P., Jolic S., Tanaskovic S. et al. Chronic Venous Disease and Comorbidities. Angiology. 2015;66(6):539–544. DOI: 10.1177/0003319714541988.
6. Rabe E., Régnier C., Goron F. et al. The prevalence, disease characteristics and treatment of chronic venous disease: an international web-based survey. J Comp Eff Res. 2020;9(17):1205–1218. DOI: 10.2217/cer-2020-0158.
7. Baev V.M., Vagapov T.F., Shmeleva S.A. Comorbidity of hypertension and chronic venous disease in men. Rossiyskiy kardiologicheskiy zhurnal. 2020;25(3):3258 (in Russ.). DOI: 10.15829/1560-4071-2020-3-3258.
8. Sinyachenko O.V., Ermolaeva M.V., Pilipenko R.V. et al. Varicose vein disease and comorbid diabetes mellitus. Report 1: Changes in carbohydrate metabolic parameters in blood from elbow and affected veins of the lower extremities. Mezhdunarodniy endokrinologicheskiy zhurnal. 2019;15(7):535–540 (in Russ.). DOI: 10.22141/2224-0721.15.7.2019.186056.
9. Baracchini C., Perini P., Calabrese M. et al. No evidence of chronic cerebrospinal venous insufficiency at multiple sclerosis onset. Ann Neurol. 2011;69(1):90–99. DOI: 10.1002/ana.22228.
10. Canhao P., Falcao F., Ferro J.M. Thrombolytics for cerebral sinus thrombosis: a systematic review. Cerebrovasc Dis. 2003;15(3):159–166. DOI: 10.1159/000068833.
11. Sun H.J., Wu Z.Y., Nie X.W., Bian J.S. Role of Endothelial Dysfunction in Cardiovascular Diseases: The Link Between Inflammation and Hydrogen Sulfide. Front Pharmacol. 2020;10:1568. DOI: 10.3389/fphar.2019.01568.
12. Castro-Ferreira R., Cardoso R., Leite-Moreira A., Mansilha A. The Role of Endothelial Dysfunction and Inflammation in Chronic Venous Disease. Ann Vasc Surg. 2018;46:380–393. DOI: 10.1016/j.avsg.2017.06.131.
13. Barthelmes J., Nägele M.P., Ludovici V. et al. Endothelial dysfunction in cardiovascular disease and Flammer syndrome-similarities and differences. EPMA J. 2017;8(2):99–109. DOI: 10.1007/s13167-017-0099-1.
14. Favero G., Paganelli C., Buffoli B. et al. Endothelium and its alterations in cardiovascular diseases: life style intervention. Biomed Res Int. 2014;2014:801896. DOI: 10.1155/2014/801896.
15. Levy J.H., Iba T., Gardiner E.E. Endothelial Injury in COVID-19 and Acute Infections: Putting the Pieces of the Puzzle Together. Arterioscler Thromb Vasc Biol. 2021;41(5):1774–1776. DOI: 10.1161/ATVBAHA.121.316101.
16. Varga Z., Flammer A.J., Steiger P. et al. Endothelial cell infection and endotheliitis in COVID-19. Lancet. 2020;395(10234):1417–1418. DOI: 10.1016/S0140-6736(20)30937-5.
17. Gustafson D., Raju S., Wu R. et al. Overcoming Barriers: The Endothelium As a Linchpin of Coronavirus Disease 2019 Pathogenesis? Arterioscler Thromb Vasc Biol. 2020;40(8):1818–1829. DOI: 10.1161/ATVBAHA.120.314558.
18. Bombardelli Е., Morazzoni P., Griffini A. Aesculus hippocastanum L. Fitoterapia. 1996;67(6):483–511. DOI:10.1201/b10413-17.
19. Zurabyan S.E. Nomenclature of natural compounds: a reference guide. M.: GEOTAR-Media; 2008 (in Russ.).
20. Frick R.W. Three treatments for chronic venous insufficiency: escin, hydroxyethylrutoside, and Daflon. Angiology. 2000;51(3):197–205. DOI: 10.1177/000331970005100303.
21. Arnould T., Janssens D., Michiels C., Remacle J. Effect of aescine on hypoxia-induced activation of human endothelial cells. Eur J Pharmacol. 1996;315(2):227–233. DOI: 10.1016/s0014-2999(96)00645-0.
22. Sirtori C.R. Aescin: pharmacology, pharmacokinetics and therapeutic profile. Pharmacol Res. 2001;44(3):183–193. DOI: 10.1006/phrs.2001.0847.
23. Ezberci F., Ünal E. Aesculus Hippocastanum (Aescin, Horse Chestnut) in the Management of Hemorrhoidal Disease: Review. Turk J Colorectal Dis. 2018;28(2):54–57. DOI: 10.4274/tjcd.16442.
24. Muravyova D.A., Samylina I.A., Yakovlev G.P. Pharmacognosy: textbook. M.: Medicine; 2002 (in Russ.).
25. Francischetti I.M., Monteiro R.Q., Guimarães J.A. Identification of glycyrrhizin as a thrombin inhibitor. Biochem Biophys Res Commun. 1997;235(1):259–263. DOI: 10.1006/bbrc.1997.6735.
26. Nakata N., Kira Y., Yabunaka Y., Takaoka K. Prevention of venous thrombosis by preoperative glycyrrhizin infusion in a rat model. J Orthop Sci. 2008;13(5):456–462. DOI: 10.1007/s00776-008-1259-x.
27. Fuhrman B., Volkova N., Kaplan M. et al. Antiatherosclerotic effects of licorice extract supplementation on hypercholesterolemic patients: increased resistance of LDL to atherogenic modifications, reduced plasma lipid levels, and decreased systolic blood pressure. Nutrition. 2002;18(3):268–273. DOI: 10.1016/s0899-9007(01)00753-5.
28. Majnskov A.V., Kiseleva T.L., Kolhir V.K. et al. Herbal medicines in the treatment of chronic venous insufficiency. M.: MOKB Mars; 1999 (in Russ.).
29. Sokolov S.J., Zamotaev I.P. Medicinal Plants: A Handbook. M.; Meditsina; 1988 (in Russ.).
30. Venskutonis P.R. Phytochemical composition and bioactivities of hawthorn (Crataegus spp.): review of recent research advances. Journal of Food Bioactives. 2018;4:69–87. DOI: 10.31665/JFB.2018.4163.
31. May J.M., Harrison F.E. Role of vitamin C in the function of the vascular endothelium. Antioxid Redox Signal. 2013;19(17):2068–2083. DOI: 10.1089/ars.2013.5205.
32. Ashor A.W., Siervo M., Lara J. et al. Effect of vitamin C and vitamin E supplementation on endothelial function: a systematic review and meta-analysis of randomised controlled trials. Br J Nutr. 2015;113(8):1182–1194. DOI: 10.1017/S0007114515000227.
33. Nađpal J.D., Lesjak M.M., Šibul F.S. et al. Comparative study of biological activities and phytochemical composition of two rose hips and their preserves: Rosa canina L. and Rosa arvensis Huds. Food Chem. 2016;192:907–914. DOI: 10.1016/j.foodchem.2015.07.089.
34. Kolkhir V.K., Voskoboynikova I.V. Composition "Angionorm”, which has anti-aggregation, capillary-protective, venotonic action. RF patent for invention RU2241483C1. Published 10.12.2004.
35. Korsun V.F., Kolhir V.K., Voskoboynikova I.V. et al. The use of angionorm after mastectomy: Guidelines. M.: RUDN; 2009 (in Russ.).
36. Korsun E.V. Report on clinical and laboratory study of the effectiveness of the domestic drug Angionorm in hemorrhoids. "Institute of phytotherapy”. M.; 2013 (in Russ.).
37. Voskoboynikova I.V., Korsun V.F., Kolhir V.K., Korsun E.V. Angionorm in the treatment of hemorrhoids. In: Collection of abstracts of the XXI Russian National Congress "Man and Medicine”. M.; 2014:29–30 (in Russ.).
38. Chuiko T.V., Korsun V.F., Voskoboynikova I.V. et al. AngioNorm® after myocardial infarction. Medicinskiy alfavit. 2016;1(8):40–44 (in Russ.).
39. Voskoboynikova I.V., Korsun V.F., Kolhir V.K., Korsun E.V. AngioNorm in postinfarction cardiosclerosis. In: Collection of abstracts of the XXI Russian National Congress "Man and Medicine”. M.; 2014:29 (in Russ.).
40. Garganeeva N.P., Barbarash O.L., Altarev S.S. et al. Antithrombotic efficacy of a domestic herbal medicine in the complex therapy of unstable angina pectoris. Lechashchij vrach. 2013;2:126–128 (in Russ.).
41. Chapaeva N.N. Angionorm in therapy of patients with chronic venous insufficiency and other vascular disorders. (Electronic resource.) URL: https://medi.ru/info/2733/ (access date: 03.03.2022) (in Russ.).

This work is licensed under a Creative Commons «Attribution» 4.0 License.
















