Algorithm for increasing the effectiveness of blood pressure control in arterial hypertension
Zagidullin N.Sh., Gareeva D.F., Sukhareva N.N.

Bashkiria State Medical University, Ufa

Now there is a great choice of antihypertensive drugs, however, it is not always possible to achieve effective control of arterial blood pressure (BP) in arterial hypertension (AH). The reasons can be both pharmacokinetic features of the drugs themselves and the features of patient’s compliance. The article attempts to create an algorithm for the selection of antihypertensive therapy based on valsartan and its combinations with hydrochlorothiazide and amlodipine with insufficient control of blood pressure in all 3 grades of BP increase, taking into account the presence of risk factors and previous therapy. The algorithm is based on studies with valsartan and its fixed combinations with hydrochlorothiazide and amlodipine, carried out in Russian patients inclusively. In particular: valsartan and its combination with hydrochlorothiazide contribute to the successful control of blood pressure and a good therapeutic effect in the majority of patients with AH of 1-2 grades. The combination of valsartan with amlodipine successfully controls arterial pressure in patients with higher grades of blood pressure increase, regardless of risk factors and concomitant diseases: the systolic and diastolic BP figures decreased to target levels in 80% of patients. Thus, an algorithm for the treatment of AH with valsartan and its combinations with hydrochlorothiazide and amlodipine as the basic antihypertensive drugs was developed. Thereby, it was possible to achieve BP control in an overwhelming number of patients at different grades of BP increase.

Key words: arterial hypertension, arterial pressure, blood pressure, combined therapy, algorithm of antihypertensive therapy, valsartan.
For citation: Zagidullin N.Sh., Gareeva D.F., Sukhareva N.N. Algorithm for increasing the effectiveness of blood pressure control in arterial hypertension // RMJ. 2017. № 20. P. 1429–1434.