Human metapneumovirus infection
DOI: 10.32364/2618-8430-2025-8-4-12
E.V. Mikhailova, T.K. Chudakova, M.S. Vaal, A.V. Romanovskaya
V.I. Razumovskiy Saratov State Medical University, Saratov, Russian Federation
The literature review is dedicated to an urgent issue (i. e., human metapneumovirus infection (MPVI)). Human metapneumovirus is a common causative agent of acute respiratory viral infections. MPVI demonstrates a broad range of clinical manifestations including both asymptomatic mild forms and severe diseases of the lower respiratory tract. Recent studies have shown that metapneumoviruses can cause damage to the lower respiratory tract associated with obstructive bronchitis, severe bronchiolitis, alvolitis, pneumonia, and bronchial asthma in children and pregnant women. In young children, metapneumoviruses often cause bronchiolitis, and they can induce exacerbation of bronchial asthma in adults and children. MPVI can complicate the course of influenza and coronavirus infection. In clinical practice, pathogenetic and symptomatic therapy is performed to treat patients with MPVI. Epitope-based vector vaccines are being developed to prevent MPVI in children and immunocompromised persons. The understanding of the role of MPVI in pediatric and obstetric practice is expanding.
Keywords: acute respiratory viral infections, metapneumovirus infection, clinical manifestations, bronchitis, bronchiolitis, pneumonia, children, pregnant women.
For citation: Mikhailova E.V., Chudakova T.K., Vaal M.S., Romanovskaya A.V. Human metapneumovirus infection. Russian Journal of Woman and Child Health. 2025;8(4):360–365 (in Russ.). DOI: 10.32364/2618-8430-2025-8-4-12
ABOUT THE AUTHORS:
Elena V. Mikhailova — Dr. Sc. (Med.), Professor, Head of the Department of Infectious Diseases in Children and Polyclinic Pediatrics named after N.R. Ivanov, V.I. Razumovskiy Saratov State Medical University; 112, Bolshaya Kazach'ya str., Saratov, 410012, Russian Federation; ORCID iD 0000-0002-3159-7351
Tatiana K. Chudakova — C. Sc. (Med.), Assistant Professor of the Department of Infectious Diseases in Children and Polyclinic Pediatrics named after N.R. Ivanov, V.I. Razumovskiy Saratov State Medical University; 112, Bolshaya Kazach'ya str., Saratov, 410012, Russian Federation; ORCID iD 0000-0002-3159-7351
Maria S. Vaal — Student at the V.I. Razumovskiy Saratov State Medical University; 112, Bolshaya Kazach'ya str., Saratov, 410012, Russian Federation; ORCID iD 0009-0007-6894-1439
Anna V. Romanovskaya — Dr. Sc. (Med.), Assistant Professor, Head of the Department of Obstetrics, Gynecology, and Reproductive Medicine, V.I. Razumovskiy Saratov State Medical University; 112, Bolshaya Kazach'ya str., Saratov, 410012, Russian Federation; ORCID iD 0000-0003-4736-2749
Contact information: Tatiana K. Chudakova, e-mail: chudakova2000@list.ru
Financial Disclosure: no authors have a financial or property interest in any material or method mentioned.
There is no conflict of interest.
Received 09.09.2024.
Revised 02.10.2024.
Accepted 25.10.2024.
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