Macrophage as a target in anti-inflammatory therapy

O.V. Filippova

I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow

Inflammation is a universal, multifactorial adaptive process in the body that provides effective immune protection. An excessive inflammatory reaction may be accompanied by tissue injury (destruction). If the immune-inflammatory response is insufficient, the process chronicity with serious structural and functional disorders of tissues and organs become possible.

One of the tasks in the anti-inflammatory therapy is to control the inflammatory process, where the possible way to control the production of pro-inflammatory cytokines and switch to the anti-inflammatory cytokines production is to influence macrophages. The article considers the macrophage role in inflammation, the conditions of macrophage activation, as well as the main mechanisms of macrophage phenotype switch (macrophage polarization). The role of purine derivatives in the macrophage activity regulation are also shown. Aminodihydrophthalazinedione sodium, acting through the adenosine receptors of macrophages, can act as one of the means capable of optimizing the body inflammatory response. The article also presents the analysis of the accumulated data on the mechanisms of action in this compound, and its administration possibilities during clinical practice in various diseases accompanied by inflammation. Furthermore, the characteristics and rational regimens with the aminodihydrophthalazinedione sodium preparations are considered.

Keywords: inflammation, cytokines, macrophages, purines, sodium aminodihydrophthalazinedione.