Reproductive Losses in In Vitro Fertilization Programs According to the Russian Association of Human Reproduction Registry Data: Possible Ways to Overcome Them
DOI: 10.32364/2618-8430-2026-9-3-5
Reproductive Losses in In Vitro Fertilization Programs According to the Russian Association of Human Reproduction Registry Data: Possible Ways to Overcome Them
A.G. Trishkin1, D.D. Lysenko1,2, G.Kh. Tolibova3,4
1 Krasnaya Gorka Center for Family Health and Reproduction LLC, Kemerovo, Russian Federation
2 Kemerovo State University, Kemerovo, Russian Federation
3 D.O. Ott Research Institute of Obstetrics, Gynecology, and Reproduction, St. Petersburg, Russian Federation
4 North Western State Medical University named after I.I. Mechnikov, St. Petersburg, Russian Federation
Aim: to analyze efficacy of assisted reproductive technology (ART) programs according to the the Russian Association of Human Reproduction (RAHR) Registry from 2019 to 2023, as well as to assess incidence of clinical pregnancies, delivery and reproductive losses in ART programs including those with and without preimplantation genetic testing (PGT).
Materials and Methods: a retrospective cohort study based on annual RAHR registry reports was performed. Embryo transfers (ET), clinical pregnancies, delivery and pregnancy losses were analyzed.
Results: a total of 601780 ETs were included within the study period. Clinical pregnancy rate was 48.9% after PGT versus 38.5% without PGT. Delivery rate per ET was 35.5% versus 26.9%, respectively. Clinical pregnancy loss rate was lower after PGT (17.2% vs 22.4%).
Conclusions: PGT was significantly associated with higher clinical pregnancy and delivery rates, as well as lower reproductive loss rates.
Keywords: assisted reproductive technologies; in vitro fertilization; PGT; preimplantation genetic testing; reproductive losses; clinical pregnancy; delivery; donor oocytes; RARH; infertility.
For citation: Trishkin A.G., Lysenko D.D., Tolibova G.Kh. Reproductive Losses in In Vitro Fertilization Programs According to the Russian Association of Human Reproduction Registry Data: Possible Ways to Overcome Them. Russian Journal of Woman and Child Health. 2026;9(3) (in Russ.). DOI: 10.32364/2618-8430-2026-9-3-5
About the authors:
Aleksey G. Trishkin — Dr. Sc. (Med.), Obstetrician-Gynecologist, Reproductive Medicine Specialist, Krasnaya Gorka Center for Family Health and Reproduction LLC; office 51, 3a, Suvorov str., Kemerovo, 650044, Russian Federation; ORCID iD 0009-0009-6012-7445
Daniil D. Lysenko — Obstetrician-Gynecologist, Krasnaya Gorka Center for Family Health and Reproduction LLC; office 51, 3a, Suvorov str., Kemerovo, 650044, Russian Federation; Teaching Assistant, Kemerovo State University; 6, Krasnaya str., Kemerovo, 650000, Russian Federation; ORCID iD 0000-0002-6410-6926
Gulrukhsor Kh. Tolibova — Dr. Sc. (Med.), Head of the Department of Pathomorphology, D.O. Ott Research Institute of Obstetrics, Gynecology, and Reproduction; 3, Mendeleevskaya line, St. Petersburg, 199034, Russian Federation; Professor of the S.N. Davydov Department of Obstetrics and Gynecology, North Western State Medical University named after I.I. Mechnikov; 41, Kirochnaya str., St. Petersburg, 191015, Russian Federation; ORCID iD 0000-0002-6216-6220
Contact information: Daniil D. Lysenko, e-mail: daniilysenko12021999@gmail.com
Financial Disclosure: no authors have a financial or property interest in any material or method mentioned.
There is no conflict of interest.
Received 21.06.2026.
Revised 14.07.2026.
Accepted 06.08.2026.
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