Stromal cell-derived factor: pathological and clinical potentialities
DOI: 10.32364/2618-8430-2020-3-3-198-204
O.V. Prokhorova1, A.A. Olina2, G.Kh. Tolibova2, T.G. Tral’2
1Ural State Medical University, Yekaterinburg, Russian Federation
2D.O. Ott Research Institute of Obstetrics, Gynecology & Reproduction, St. Petersburg, Russian Federation
Chemotactic cytokines are a family of signaling proteins secreted by various human tissues. Their functioning is based on the ability to induce directed chemotaxis in nearby susceptible cells. This paper reviews recent published data on one of the most important homeostatic cytokines, stromal cell-derived factor-1 (SDF-1). The leading role of this factor in the pathogenesis of various conditions, i.e., toxic, ischemic, and necrotic tissue damage, carcinogenesis (including the mechanisms of invasion and metastasis) is demonstrated. SDF-1 acts as a powerful inductor of angiogenesis and stimulates the proliferation of endothelial cells in reproductive organs. This chemokine is one of the candidate factors involved in the regulation of proliferation and differentiation of human endometrium, i.e., the implementation of epithelial-stromal interaction of tissue elements in uterine mucosa. Clear understanding of the regulatory mechanisms of SDF-1-mediated signaling during trophoblast functioning and placental angiogenesis may help develop novel therapeutic approaches to pregnancy-related disorders.
Keywords: stromal cell-derived factor, chemokines, cytokines, pathogenesis, pregnancy, homeostasis.
For citation: Prokhorova O.V., Olina A.A., Tolibova G.Kh., Tral’ T.G. Stromal cell-derived factor: pathological and clinical potentialities. Russian Journal of Woman and Child Health. 2020;3(3):198–204. DOI: 10.32364/2618-8430-2020-3-3-196-204.
About the authors:
Olga V. Prokhorova — Cand. of Sci. (Med.), associate professor of the Department of Obstetrics & Gynecology of the Faculty of Advanced Training & Professional Retraining, Ural State Medical University, 3, Repin str., Yekaterinburg, 620028, Russian Federation, ORCID iD 0000-0002-9051-4528.
Anna A. Olina — Doct. of Sci. (Med.), Professor, First Deputy Director, D.O. Ott Research Institute of Obstetrics, Gynecology, & Reproduction, 3, Mendeleevskaya line, St. Petersburg, 199034, Russian Federation, ORCID iD 0000-0001-9101-7569.
Gulrukhsor Kh. Tolibova — Doct. of Sci. (Med.), Head of the Laboratory of Immunohistochemistry, D.O. Ott Research Institute of Obstetrics, Gynecology, & Reproduction, 3, Mendeleevskaya line, St. Petersburg, 199034, Russian Federation, ORCID iD 0000-0002-6216-6220.
Tat’yana G. Tral’ — Cand. of Sci. (Med.), Head of the Department of Pathological Anatomy, D.O. Ott Research Institute of Obstetrics, Gynecology, & Reproduction, 3, Mendeleevskaya line, St. Petersburg, 199034, Russian Federation, ORCID iD 0000-0001-8948-4811.
Contact information: Olga V. Prokhorova, e-mail: prokhorova-ov@yandex.ru. Financial Disclosure: no authors have a financial or property interest in any material or method mentioned. There is no conflict of interests. Received 10.08.2020, revised 24.08.2020, accepted 07.09.2020.
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