Initial treatment of climacteric syndrome in the transitional menopausal period
Tatarova N.A.^1,2, Hayrapetyan M.S. ^1, Zhigalova E.V. <sup>1,2

1</sup> The First Saint-Petersburg State Medical University named after Academician I.P. Pavlov
² «I-Clinic NW», St. Petersburg

Misadaption processes have a leading role in the transitional menopausal period, and  therefore develop menopausal metabolic syndrome (MMS) –a weight gain with the formation of abdominal obesity, insulin resistance and dyslipidemia and/or hypertension.  In order to relieve the menopausal symptoms and to prevent the diseases that accompany aging, doctors usually appoint the diet, exercises, smoking cessation, as well as the menopausal hormone therapy (MHT) or phytoestrogens and plant hormones. Alternative methods of menopausal disorders correction have the mechanism of action similar to hormonal therapy, but they do not have negative side effects (proliferative activity in myometrium and endometrium, mammary gland, increasing the risk of thrombosis). Complex drugs with phytoestrogens, antioxidants, and vitamins are considered to be the most effective alternative drugs.
The aim of the study was to evaluate the efficacy and safety of the food supplement Estrovel (capsules) in women with climacteric syndrome (CS) in the transitional menopausal period.
Patients and methods. We conducted a non-randomized placebo-uncontrolled prospective comparative clinical study involving 25 women (aged from 48 to 53 years) with moderate CS symptoms. The severity of CS was estimated using the modified menopausal index (MMI). The presence of CS symptoms was the reason for the appointment of a non-hormonal menopausal therapy by Estrovel.
Results. Estrovel is a food supplement of natural origin, it reduces the number and intensity of hot flashes, irritability, nervousness, breast tenderness, bloating, headaches, improves sleep quality, relieves night sweats, reduces muscle pain in women in the menopausal transition period. After 2 months treatment by this drug all of the patients noted a moderate and high level of life satisfaction when assessing the quality of their life.
Conclusions. Estrovel has a positive effect on the  CS symptoms: it normalizes the female endocrine and lipid profile, providing a positive impact on hepatobiliary system; eases the symptoms of menopause; helps to prevent cardiovascular disease; reduces the risk of thrombosis.

Key words: menopause, phytoestrogens, food supplement, Estrovel.
For citation: Tatarova N.A., Hayrapetyan M.S., Zhigalova E.V. Initial treatment of climacteric syndrome in the transitional menopausal period // RMJ. 2017. № 2. P. 98–103.