Novel modalities for medical prevention of coagulopathy bleeding in C–section
Sinchikhin S.P., Sarbasova A.E., Stepanyan L.V., Mamiev O.B.

Astrakhan State Medical University

Background. The paper describes a method of coagulopathy bleeding prevention in C–section (Certificate of Acceptance No.2016129336; July 18, 2016) which involves intravenous injection of 10 ml of 10% calcium gluconate and subsequent injection of 10 ml (1 g dry matter) of tranexamic acid when performing abdominal wall incision.
Aim. To assess the efficacy of intraoperative combined use of 10 ml of 10% calcium gluconate and 1.0 g of tranexamic acid in the course of C–section in women with abnormal fibrinolysis.
Patients and methods. Prospective study included 160 women with high risk of coagulopathy bleeding. The patients were subdivided into groups and subgroups 40 women each. In group I, calcium gluconate and tranexamic acid were subsequently administered in the course of C–section. In group IIA, only calcium gluconate was used. In group IIB, only tranexamic acid was used. In group III, neither of these agents was administered.
Results. Complex treatment with calcium gluconate and tranexamic acid demonstrated higher clinical efficacy as compared with other treatments. These women reported on early global improvement after endotracheal narcosis.
Conclusions. These medicines are highly effective for reducing hemorrhage during C–section in women with abnormal fibrinolysis. Definitive and predominantly positive effect of this technique as compared with other methods to reduce perioperative hemorrhage in the course of C–section was demonstrated. Clinical application of this technique is cost–beneficial thus preventing intra– and postoperative complications and reducing hospital stay.

Key words: cesarean section, bleeding prevention, Tranexam, calcium gluconate.
For citation: Sinchikhin S.P., Sarbasova A.E., Stepanyan L.V. et al. Novel modalities for medical prevention of coagulopathy bleeding in C–section // RMJ. 2017. № 2. P. 76–84.