Hormonal contraception and venous thromboembolic complications in women
Demekhova M.Yu. 

«Medalp» LLC, St. Petersburg

Hormonal drugs used for contraception, hormone replacement therapy and correction of the symptoms of menopause are widely used throughout the world. However, the use of hormonal drugs is associated with an increased risk of venous thromboembolic complications (VTEC), such as deep vein thrombosis and pulmonary embolism. The purpose of this work is the compilation of an algorithm for choosing hormone therapy from the point of view of a phlebologist, taking into account the risk factors for the development of VTEC. The author analyzes the literature from Medline (PubMed) and Cochrane databases. It has been revealed that hormonal therapy with combined oral contraceptives increases the risk of venous thrombosis in the general population by more than 2 times. However, there was a decrease in risk as the duration of use and the estrogen dose were reduced. With the same dose of estrogen and the same duration of use, oral contraceptives with desogestrel, gestodene or drospirenone are associated with a significantly higher risk of venous thrombosis than oral contraceptives with levonorgestrel. Preparations containing only progestogens and hormone releasing intrauterine devices (coils) were not associated with an increased risk of developing VTEC.
Key words: hormonal therapy, combined oral contraceptives, methods of contraception, hormone replacement therapy, deep vein thrombosis, pulmonary embolism, phlebotonics, Escuzan.
For citation: Demekhova M.Yu. Hormonal contraception and venous thromboembolic complications in women // RMJ. 2017. № 12. P. 884–888.