Safety and efficacy of myomectomy: results of a single-center cohort study
DOI: 10.32364/2618-8430-2025-8-1-3
B.A. Slobodyanyuk1,2, Yu.E. Dobrokhotova1, V.I. Dimitrova2, E.A. Markova1,2, O. A. Slyusareva2, L.Ya. Abbasova1, A.V. Putrya1, A.R. Mudarisova1, V.A. Ushakova1, D.A. Fedyaev3, A.A. Zaripova1, A.I. Yaratova1
1Pirogov Russian National Research Medical University, Moscow, Russian Federation
2F.I. Inozemtsev City Clinical Hospital, Moscow, Russian Federation
3N.V. Sklifosovsky Research Institute for Emergency Medical Aid, Moscow, Russian Federation
Aim: to evaluate the outcomes of myomectomy and the incidence of intraoperative and postoperative complications.
Patients and Methods: between January 2019 and December 2022, a total of 268 myomectomies were performed. The surgeries utilized both laparoscopic and laparotomic techniques. A database was developed to collect and analyze information on the female patients included in the study. The data were collected retrospectively by reviewing medical records and patient questionnaires. Among the 268 patients, complete data were obtained for 219.
Results: the size of the fibroids ranged from 4 to 25 cm, with an average diameter of 9.02 cm. Uterine cavity deformities were observed in 56/268 (20.89%) patients, and uterine cavity dissection was noted in 52/268 (19.4%). A correlation was identified between the volume of blood loss and both the number of removed fibroid nodes (p=0.072) and the diameter of the largest node (p<0.01). In the postoperative period: 10/268 (3.73%) patients experienced dynamic bowel obstruction, which resolved spontaneously; 18/268 (6.72%) patients had a fever; 13/268 (4.85%) patients developed lower urinary tract infections; 1/268 (0.37%) patient experienced suture site suppuration; 1/268 (0.37%) patient developed a postoperative hernia. During follow-up, 32/219 (14.61%) female patients experienced recurrence of fibroids, of whom 1/219 (0.46%) underwent repeated surgery. No intraoperative complications, such as bladder or bowel injuries, or unplanned hysterectomies were reported. At the time of the survey, 35/219 (15.98%) women successfully restored their reproductive function, achieving pregnancy and delivery. All children born were healthy. No cases of uterine scar failure were identified intraoperatively or via follow-up pelvic ultrasound.
Conclusion: laparoscopic myomectomy is a safe and effective surgical treatment for uterine fibroids, with a low incidence of complications, even during subsequent pregnancies.
Keywords: uterine fibroids, laparoscopic myomectomy, pregnancy, complications, laparoscopy, intraoperative complications, postoperative complications.
For citation: Slobodyanyuk B.A., Dobrokhotova Yu.E., Dimitrova V.I., Markova E.A., Slyusareva O. A., Abbasova L.Ya., Putrya A.V., Mudarisova A.R., Ushakova V.A., Fedyaev D.A., Zaripova A.A., Yaratova A.I.Safety and efficacy of myomectomy: results of a single-center cohort study. Russian Journal of Woman and Child Health. 2025;8(1):20–26 (in Russ.). DOI: 10.32364/2618-8430-2025-8-1-3
ABOUT THE AUTHORS:
Boris A. Slobodyanyuk — C. Sc. (Med.), Associate Professor of the Department of Obstetrics and Gynecology of the Institute of Surgery, Pirogov Russian National Research Medical University; 1, Ostrovityanov str., Moscow, 117997, Russian Federation; obstetrician-gynecologist of the Department of Gynecology, F.I. Inozemtsev City Clinical Hospital; 1, Fortunatovskaya str., Moscow, 105187, Russian Federation; ORCID iD 0009-0005-9578-1755
Yulia E. Dobrokhotova — Dr. Sc. (Med.), Professor, Head of the Department of Obstetrics and Gynecology, Faculty of General Medicine, Pirogov Russian National Research Medical University; 1, Ostrovityanov str., Moscow, 117513, Russian Federation; ORCID iD: 0000-0002-7830-2290
Valentina I. Dimitrova — C. Sc. (Med.), obstetrician-gynecologist of the Department of Gynecology, F.I. Inozemtsev City Clinical Hospital; 1, Fortunatovskaya str., Moscow, 105187, Russian Federation.
Eleonora A. Markova — C. Sc. (Med.), Associate Professor of the Department of Obstetrics and Gynecology of the Institute of Surgery, Pirogov Russian National Research Medical
University; 1, Ostrovityanov str., Moscow, 117997, Russian Federation; obstetrician-gynecologist of the Department of Gynecology, F.I. Inozemtsev City Clinical Hospital; 1, Fortunatovskaya str., Moscow, 105187, Russian Federation; ORCID iD 0000-0002-9491-9303
Olga A. Slyusareva — C. Sc. (Med.), obstetrician-gynecologist of the Department of Gynecology, F.I. Inozemtsev City Clinical Hospital; 1, Fortunatovskaya str., Moscow, 105187, Russian Federation; ORCID iD 0000-0001-9279-7851
Leila Yashar kyzy Abbasova — 1st-year clinical resident at the Department of Obstetrics and Gynecology of the Institute of Surgery, Pirogov Russian National Research Medical University; 1, Ostrovityanov str., Moscow, 117437, Russian Federation; ORCID iD 0009-0006-1701-8620
Anna V. Putrya — 1st-year clinical resident at the Department of Obstetrics and Gynecology of the Institute of Surgery, Pirogov Russian National Research Medical University; 1, Ostrovityanov str., Moscow, 117437, Russian Federation; ORCID iD 0009-0003-6628-3357
Arina R. Mudarisova — 1st-year clinical resident at the Department of Oncology, Hematology and Radiation Therapy of the Institute of Motherhood and Childhood, Pirogov Russian National Research Medical University; 1, Ostrovityanov str., Moscow, 117437, Russian Federation; ORCID iD 0009-0001-9868-7239
Veronika A. Ushakova — 4th-year student of the Faculty of Medicine, Pirogov Russian National Research Medical University; 1, Ostrovityanov str., Moscow, 117437, Russian Federation; ORCID iD 0009-0000-0424-0165
Denis A. Fedyaev — 1st-year clinical resident specializing in Cardiovascular Surgery, N.V. Sklifosovsky Research Institute for Emergency Medical Aid; 3, Bolshaya Sukharevskaya Square, Moscow, 129090, Russian Federation; ORCID iD 0009-0009-7172-3496
Almira A. Zaripova — 5th-year student of the Faculty of Medicine, Pirogov Russian National Research Medical University; 1, Ostrovityanov str., Moscow, 117437, Russian Federation; ORCID iD 0009-0007-3160-778
Alina I. Yaratova — 4th-year student of the Faculty of Medicine, Pirogov Russian National Research Medical University; 1, Ostrovityanov str., Moscow, 117437, Russian Federation; ORCID iD 0009-0006-9223-0314
Contact information: Boris A. Slobodyanyuk, e-mail: borisslo@inbox.ru
Financial Disclosure: no authors have a financial or property interest in any material or method mentioned.
There is no conflict of interest.
Received 02.07.2024.
Revised 25.07.2024.
Accepted 19.08.2024.
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