Eternal intrigue of gastritis

M.F. Osipenko, E.A. Bikbulatova, Yu.V. Makarova, V.P. Drobysheva

Novosibirsk State Medical University, Novosibirsk

The article discusses the issues of classification, etiology, pathogenesis, diagnosis and treatment of gastritis, including chronic gastritis (CG). Currently, CG is defined as a long-term and usually non-self-limiting inflammation of the gastric mucosa (GM). The disease commonly lasts for life with the constant impact of an etiological factor. The most common etiological factor of CG is Helicobacter pylori. Gastritis caused by H. pylori can progress from non-atrophic to atrophic with further progression to gastric cancer. The authors also consider other forms of CG, including autoimmune and drug-induced gastritis, as well as the modern possibilities of CG treatment, such as the use of medicines aimed not only at eliminating the aggressive factor but also at enhancing the protective properties of GM, acid-forming and pepsin-forming functions of the stomach. The results of clinical studies concerning alpha-glutamyl-tryptophan, which has a reparative, anti-inflammatory and enveloping effect and is used in the complex treatment of chronic atrophic gastritis, as well as the own case study of a female patient with atrophic gastritis, are presented.

Keywords: chronic gastritis, chronic atrophic gastritis, gastric mucosa, Helicobacter pylori, alpha-glutamyl-tryptophan, acid-forming function of the stomach, pepsin-forming function of the stomach.

For citation: Osipenko M.F., Bikbulatova E.A., Makarova Yu.V., Drobysheva V.P. Eternal intrigue of gastritis. RMJ. 2024;10:–36. DOI: 10.32364/2225-2282-2024-10-6