Сase of common eosinophilic infiltrates of the gastrointestinal tract

A.V. Kuzmina¹, N.V. Novozhilov¹, A.Yu. Trebushenkov¹, D.V. Bulanov¹, A.A. Zhambeev¹, E.V. Zhilyaev^1-3

¹European Medical Center, Moscow

²Pirogov Russian National Research Medical University, Moscow

³Russian Medical Academy of Continuous Professional Education, Moscow

Eosinophilic gastrointestinal disorders are a group of diseases characterized by dense eosinophilic tissue infiltration of various organs in the gastrointestinal tract, leading to morphological and functional disorders, such as eosinophilic esophagitis, eosinophilic gastritis, eosinophilic gastroenteritis and eosinophilic colitis. The article presents a clinical case of a 17-year-old male patient with a common eosinophilic disease involving the esophagus, stomach, small and large intestines. The disease was manifested by nausea, vomiting, diarrhea and significant eosinophilia. The diagnosis was confirmed by laboratory and morphological data. The disease course was complicated by cervical lymphadenitis with phlebitis and jugular vein thrombosis, which regressed during antibacterial and anticoagulant therapy. Disease regression was achieved during treatment with ketotifen and medium doses of glucocorticoid. Based on the literature data, the authors discussed modern approaches to the diagnosis and treatment of eosinophilic diseases. The peculiarity of the case was the uncommon process spreading from the gastroesophageal junction to the cecum,  as well as an uncommon complication in the form of left-sided supraclavicular lymphadenitis occurrence, complicated by subclavian vein thrombosis and internal jugular vein thrombosis.

Keywords: eosinophilic esophagitis, eosinophilic gastritis, eosinophilic enterocolitis, lymphadenitis.

For citation: Kuzmina A.V., Novozhilov N.V., Trebushenkov A.Yu. et al. Сase of common eosinophilic infiltrates of the gastrointestinal tract. RMJ. 2021;10:31–35.