NSAID-associated dyspepsia. Possibilities of therapeutic correction
Pakhomova I.G.1, Kuchmin A.N.2
1 North-western State Medical University named after I.I. Mechnikov, St. Petersburg
2 Military Medical Academy named after S.M. Kirov of the Ministry of Defense of Russia, St. Petersburg
Non-steroidal anti-inflammatory drugs (NSAIDs) are one of the most widely used group of drugs in clinical practice. The use of NSAIDs is associated with a risk of side effects from the gastrointestinal tract, which can cause serious complications. NSAID-induced gastropathy is well studied and described, in most cases it is asymptomatic even in the presence of erosive-ulcerative changes. However, the intake of NSAIDs may be associated with various unpleasant sensations from the upper gastrointestinal tract (often in the absence of an endoscopically determined lesion of the mucosa) that must be considered in the context of another possible complication, namely, NSAID-associated dyspepsia. Unfortunately, often this problem is not considered by doctors as important or serious. However, it is the subjective sensations that cause the greatest concern of patients and significantly affect their compliance to the therapy. The article examines the clinical and pathogenetic mechanisms of the development of NSAID-associated dyspepsia, as well as therapeutic tactics in the management of such patients, with the possibility of prescribing not only effective, but also safe drugs for treating the symptoms.
Key words: NSAID-associated dyspepsia, gastroesophageal reflux, NSAIDs, PPI, pantoprazole.
For citation: Pakhomova I.G., Kuchmin A.N. NSAID-associated dyspepsia. Possibilities of therapeutic correction // RMJ. Medical Review. 2018. № 3. P. 35–38.
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