The magnesium-zinc status at patients with chronic hepatitises B and C
Plotnikova E.Yu.1, Кaryagina M.S.2, Shamray M.A.2, Zinchuk S.F.1, Baranova E.N.1, Maximov S.A.4
1 Kemerovo State Medical University
2 Regional clinical hospital of emergency medical service named after M.A. Podgorbunsky, Kemerovo
3 Scientific research institute of Complex problems of cardiovascular diseases, Kemerovo
Viral hepatitis takes the second place in the world after the flu and acute respiratory infections in terms of the prevalence and incidence rate. The study of the peculiarities of the violation of the links of the mineral metabolism in viral hepatitis makes it possible to detail the general picture of this disease, and, therefore, to optimize the approaches to its treatment. The article presents the role of magnesium and zinc in the human body in normal and chronic viral hepatitis. The problem of their deficiency in the body with chronic viral hepatitis C and B is described.
Aim: to assess the level of tissue magnesium and zinc in patients with chronic hepatitis B and C. Compare the results with the level of tissue magnesium and zinc in healthy people in the control group.
Patients and methods: magnesium-zinc status in tissues in 119 people with chronic hepatitis B and C was studied by mass spectrometry. The control group consisted of 30 healthy people. The reference magnesium values in nails in men are 45-105 μg / g, in women 90-300 μg / g. The reference values of zinc in the nails in men are 180-240 μg / g, in women 216-276 μg / g. Since the reference values of tissue magnesium and zinc differed in men and women, in each group the patients were divided by gender.
Results: it was revealed that chronic hepatitis B and C were accompanied by tissue magnesium and zinc deficiency. The tissue levels of magnesium and zinc in these patients correlated with some biochemical hepatic markers, as well as with the results of the assessment of the motor function of the biliary tract.
Conclusions: the obtained data justify the need to include a study of the level of tissue magnesium and zinc into a complex examination of patients suffering from liver diseases, and the use of complex therapies of magnesium and zinc-containing drugs in the treatment schemes helps to optimize the treatment.
Key words: chronic viral hepatitis, chronic hepatitis B, chronic hepatitis C, magnesium, zinc, magnesium deficiency, zinc deficiency.
For citation: Plotnikova E.Yu., Кaryagina M.S., Shamray M.A. et al. The magnesium-zinc status at patients with chronic hepatitises B and C // RMJ. MEDICAL REVIEW. 2017. № 2. P. 60 –64.
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3. Городецкий В.В., Талибов О.Б. Препараты магния в медицинской практике. Малая энциклопедия магния. М.: Медпрактика, 2008. 43 с. [Gorodeckij V.V., Talibov O.B. Preparaty magniya v medicinskoj praktike. Malaya ehnciklopediya magniya. M.: Medpraktika, 2008. 43 s. (in Russian)].
4. Rocchi E., Borella P., Borghi A. et al. Zinc and magnesium in liver cirrhosis // European Journal of Clinical Investigation. 1994. Vol. 24(3). P. 149–155.
5. Ильина E.H., Роворун В.М., Иваников И.О. Некоторые аспекты лабораторной диагностики вирусных гепатитов В и С // Терапевт. арх. 2003. Т. 75(4). С. 84–86 [Il'ina E.N., Rovorun V.M., Ivanikov I.O. Nekotorye aspekty laboratornoj diagnostiki virusnyh gepatitov V i S // Terapevt. arh. 2003. T. 75(4). S. 84–86 (in Russian)].
6. Пузанов В.А. Изменение магниевого статуса человека в норме и при гепатитах и возможные пути его коррекции: Дис. … канд. мед. наук. 2003. 65 с. [Puzanov V.A. Izmenenie magnievogo statusa cheloveka v norme i pri gepatitah i vozmozhnye puti ego korrekcii: Dis. … kand. med. nauk. 2003. 65 s. (in Russian)].
7. Fredricks R.E., Tanaka K.R., Valentine W.N. Zinc in human blood cells: normal values and abnormalities associated with liver disease // J. Clin. Invest. 1960. Vol. 39. P. 1651–1656.
8. Vikbladh I. Studies on zinc in blood II // Scand. J. Clin. Lab. Invest. 1950. Vol. 3(2). № 2. P. 143–148.
9. Kisters K., Spieker C., Nguyen S. Q. et al. Zinc concentrations in human liver tissue and in blood plasma in cirrhosis of the liver due to alcoholism // Trace Elements and Electrocytes. 1994. Vol. 11(3). P. 101–103.
10. Rocchi E., Borella P., Borghi A. et al. Zinc and magnesium in liver cirrhosis. // European Journal of Clinical Investigation. 1994. Vol. 24(3). P. 149–155.
11. Bode J.C., Hanisch P., Henning H. et al. Hepatic zinc content in patients with various stages of alcoholic liver disease and in patients with chronic active and chronic persistent hepatitis // Hepatology. 1988. Vol. 8. P. 1605–1609.
12. Nandi S.S., Chawla Y.K., Nath R. et al. Serum and urinary zinc in fulminant hepatic failure. // J. Gastroenterol. Hepatol. 1989. Vol. 4. P. 209–213.
13. Ebara M., Fukuda H., Hatano R. et al. Metal contents in the liver of patients with chronic liver disease caused by hepatitis C virus. Reference to hepatocellular carcinoma // Oncology. 2003. Vol. 65. Р. 323–330.
14. Choo Q.L., Kuo G., Weiner A.J. et al. Isolation of a cDNA clone derived from a blood – borne non-A, non-B viral hepatitis genome // Science. 1989. Vol. 244. P. 359–362.
15. Ishikawa T. Can zinc enhance response interferon therapy for patients with HCV-related liver disease? // World J. Gastroenterol. 2012. Vol. 18(25). P. 3196–3200.
16. Wang-Sheng K., Chih-Hung G., Maw-Sheng Y. et al. Blood micronutrient, oxidative stress, and viral load in patients with chronic hepatitis C // World J. Gastroenterol. 2005. Vol. 11(30). P. 4697–4700.
17. Moriyama M., Matsumura H., Fukushima A. et al. Clinical significance of evaluation of serum zinc concentrations in C-viral chronic liver disease // Dig. Dis. Sci. 2006. Vol. 51. P. 1967–1977.
18. Schregel V., Jacobi S., Penin F. et al. Hepatitis C virus NS2 is a protease stimulated by cofactor domains in NS3 // Proc Natl. Acad. Sci . USA. 2009. Vol. 106. P. 5342–5347.
19. Loguercio C., De Girolamo V., Federico A. et al. Trace elements and chronic liver diseases // J Trace Elem Med Biol. 1997. Vol. 11. P. 158–161.
20. Himoto T., Hosomi N., Nakai S. et al. Efficacy of zinc administration in patients with hepatitis C virus-related chronic liver disease // Scand. J. Gastroenterol. 2007. Vol. 42(9). P. 1078–1087.
21. Matsuoka S., Matsumura H., Nakamura H. et al. Zinc supplementation improves the outcome of chronic hepatitis C and liver cirrhosis // J Clin. Biochem. Nutr. 2009. Vol. 45. P. 292–303.
22. Prasad A.S. Effects of zinc deficiency on Th1 and Th2 cytokine shifts // Journal of Infectious Disease. 2000. Vol. 182(3). P. 62–68.
23. Дегоева Б.А. Нарушения элементного статуса и его коррекция у больных с хроническими заболеваниями печени: Дис. … канд. мед. наук. М., 2005. 118 с. [Degoeva B.A. Narusheniya ehlementnogo statusa i ego korrekciya u bol'nyh s hronicheskimi zabolevaniyami pecheni: Dis. … kand. med. nauk. M., 2005. 118 s. (in Russian)].
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