Cholestatic liver diseases: diagnostic and treatment algorithms

T.E. Polunina

A.I. Yevdokimov Moscow State University of Medicine and Dentistry, Moscow

Over the past decade, significant progress has been made in understanding the molecular basis of bilification and the cholestasis pathophysiology. The article presents the goals of cholestasis therapy, which help to understand existing treatment methods and contribute to the development of new drugs for cholestatic liver diseases (CLD). This article also briefly summarizes the current concepts of bilification and cholestasis occurrence. Treatment of CLD is illustrated by the example of the most common chronic cholestatic liver disease — primary biliary cholangitis.

Keywords: bile, cholestasis, cholestatic liver diseases, primary biliary cholangitis, ursodeoxycholic acid.

For citation: Polunina T.E. Cholestatic liver diseases: diagnostic and treatment algorithms. RMJ. 2021;6:81–87 (in Russ.).