Probiotic therapy evolution in the clinical practice of internal medicine

A.N. Kazyulin, A.Yu. Goncharenko, E.E. Pavleyeva, I.E. Kalyagin

Moscow State University of Medicine and Dentistry

The article is devoted to the microbiota role in the human body. It has been alleged that the microbiota normal condition is accepted as one of the human health indicators. The article describes the following: diseases associated with intestinal microbiocenosis disorders, the causes of its violation; the history of the term “probiotics”; the clinical effects of their use. The necessity of microbiocenosis adequate correction and maintenance as a preventive and therapeutic measure with agents of probiotic activity is proved. The requirements for modern probiotics, following which served as the causal evolution of their types, are listed in detail. Probiotics characteristics of four generations with the causal data on the insufficient clinical efficiency of first-generation agents are given. The article presents distinctive characteristics of the fourth-generation  agents with a unique revolutionary double layer-coated system (developed and registered by Cell Biotech), using an example of a probiotic produced with this technique, registered in the Russian Federation under the trade name Neobiotic Lactobalance^®. Also, the experimental and randomized clinical trials data confirming the probiotics effectiveness and their high potential for the treatment of various diseases, both in the monotherapy and as part of complex treatment, are presented. From the standpoint of evidence-based medicine, there is a necessity of further clinical studies to determine all possible clinical effects of probiotics concerning various nosology.

Keywords: microbiota, intestinal microbiocenosis disorder, probiotics, modern requirements, double-coated probiotics, clinical effects.

For citation: Kazyulin A.N., Goncharenko A.Yu., Pavleyeva E.E., Kalyagin I.E. Probiotic therapy evolution in the clinical practice of internal medicine. RMJ. 2019;12:89–96.