Biliary sludge as a pre-stone stage of cholelithiasis. Clinical cases of Himecromone application
DOI: 10.32364/2587-6821-2025-9-5-6
E.Ya. Selezneva, Yu.V. Embutnieks, M.V. Bernaz, T.A. Mechetina, E.S. Koricheva
A.S. Loginov Moscow Clinical Scientific Center, Moscow, Russian Federation
The paper reviews the current literature on biliary sludge (BS), a pre-stone stage of cholelithiasis. Risk factors, unresolved issues of primary prevention of cholelithiasis, etiopathogenetic mechanisms, methods of diagnosis and treatment of functional biliary disorders and BS are considered. Clinical case reports in BS patients demonstrate efficacy of combined therapy (Ursodeoxycholic acid + Himecromone, a selective antispasmodic). Both patients had risk factors for BS (genetic predisposition, pregnancy, and low-calorie diet). Based on the literature data and the authors' own experience, the authors concluded that timely diagnosis and treatment of functional biliary disorder and BS are important to prevent cholelithiasis.
Keywords: biliary sludge, biliary dysfunctions, ursodeoxycholic acid, himecromone.
For citation: Selezneva E.Ya., Embutnieks Yu.V., Bernaz M.V., Mechetina T.A., Koricheva E.S. Biliary sludge as a pre-stone stage of cholelithiasis. Clinical cases of Himecromone application. Russian Medical Inquiry. 2025;9(5):291–296 (in Russ.). DOI: 10.32364/2587-6821-2025-9-5-6
About the authors:
Elmira Ya. Selezneva — Dr. Sc. (Med.), Head of the Department of Outpatient Hospital, A.S. Loginov Moscow Clinical Scientific Center; 1, build. 1, Novogireevskaya str., Moscow, 111123, Russian Federation; ORCID iD 0000-0003-3895-5964
Yulia V. Embutnieks — Dr. Sc. (Med.), Head of the Department of Diseases of the Upper Digestive Tract, A.S. Loginov Moscow Clinical Scientific Center; 1, build. 1, Novogireevskaya str., Moscow, 111123, Russian Federation; ORCID iD 0000-0002-6479-9515
Mariya V. Bernaz — Gastroenterologist, Consultative and Diagnostic Department, A.S. Loginov Moscow Clinical Scientific Center; 1, build. 1, Novogireevskaya str., Moscow, 111123, Russian Federation; ORCID iD 0009-0005-6777-438X
Tatiana A. Mechetina — C. Sc. (Med.), Gastroenterologist, Therapeutic Outpatient Hospital, A.S. Loginov Moscow Clinical Scientific Center; 1, build. 1, Novogireevskaya str., Moscow, 111123, Russian Federation; ORCID iD 0009-0006-3298-2901
Ekaterina S. Koricheva — C. Sc. (Med.), Gastroenterologist, Therapeutic Outpatient Hospital, A.S. Loginov Moscow Clinical Scientific Center; 1, build. 1, Novogireevskaya str., Moscow, 111123, Russian Federation; ORCID iD 0009-0009-2739-8008
Contact information: Elmira Ya. Selezneva, e-mail: e.selezneva@mknc.ru
Financial Disclosure: no authors have a financial or property interest in any material or method mentioned.
There is no conflict of interest.
Received 11.04.2025.
Revised 12.05.2025.
Accepted 29.05.2025.
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