Antacids: whether they are in demand in the era of proton pump inhibitors?
Simanenkov V.I., Tikhonov S.V., Lishchuk N.B.

Northwestern State Medical University named after I. I. Mechnikov, St. Petersburg

Acid-related diseases (ARD), of course, are the actual problem of modern gastroentorology. The hydrochloric acid produced by the parietal cells of the stomachplays a significant role in the pathogenesis of this group of diseases. The symptoms of ARD, dominated by heartburn, regurgitation and epigastric pain have a marked negative impact on patients' quality of life and lead to significant financial costs.The basic approach to the treatment of these pathologies is to effect the production of hydrochloric acid by the parietal cells and/or binding of acid in the lumen of the stomach.Currently, proton pump inhibitors (PPIs) are the primary agents for the treatment of acid-related diseases.Despite the fact that antacids are inferior to PPIS in the expression of acid-suppressive activity, in some situations they are preferable. The review is devoted to the advantages of antacid drugs, in particular the speed of their actions, the impact on non-acidic duodenal and gastro-oesophageal refluxes.Special attention is paid to the clinical application of the combined drug containing calcium carbonate and magnesium carbonate (Rennie®).

Key words: acid-related disease, GERD, antacids, calcium carbonate, magnesium carbonate, on-demand therapy, non-acidic refluxes, acid pocket.
For citation: Simanenkov V.I., Tikhonov S.V., Lishchuk N.B. Antacids: whether they are in demand in the era of proton pump inhibitors? // RMJ. 2017. № 3. P. 157–161.