Diagnosis of bacteriologically unconfirmed pulmonary tuberculosis (literature review)
DOI: 10.32364/2587-6821-2022-6-7-387-392
T.E. Tyulkova1, T.K. Lugovkina2, D.M. Kutuzova1, N.F. Khabibullina1
1National Medical Research Center of Phtysiopulmonology, Moscow, Russian Federation
2Ural Scientific Research Institute of Phtysiopulmonology — Branch of the National Medical Research Center of Phtysiopulmonology, Yekaterinburg, Russian Federation
The authors analyzed 31 scientific publications, which highlighted modern methods to the diagnosis of bacteriologically unconfirmed pulmonary tuberculosis (PTB). In the article, such clinical cases are classified into two groups due to the absence of the tuberculosis causative agent. This approach can serve as a justification for choosing optimal and appropriate additional methods and techniques for diagnosing bacteriologically unconfirmed PTB. Given the fact that bacterial excretion is determined by traditional microbiological methods (microscopic and cultural) in sputum, the literature review presents data on additional measures for obtaining biological material for the etiological diagnosis of tuberculosis, using molecular genetic methods for detecting Mycobacterium tuberculosis DNA. Besides, the article shows the diagnostic significance of immunological and serological tests for the tuberculosis diagnosis, as well as modern methods to the X-ray results interpretation, using mathematical methods that evaluate the dynamic X-ray imaging. A special place in the bacteriologically unconfirmed PTB diagnosis is occupied by the description of biopsy material using artificial intelligence. That is, the integration of medicine and information technology achievements allows us having a source of additional information that should help the doctor diagnose tuberculosis in difficult clinical cases.
Keywords: tuberculosis, oligobacillar forms of tuberculosis, sputum smear-negative tuberculosis, diagnosis, bacteriologically unconfirmed, diagnostic material, immunological methods, radiation methods, mathematical methods.
For citation: Tyulkova T.E., Lugovkina T.K., Kutuzova D.M., Khabibullina N.F. Diagnosis of bacteriologically unconfirmed pulmonary tuberculosis (literature review). Russian Medical Inquiry. 2022;6(7):387–392 (in Russ.). DOI: 10.32364/2587-6821-2022-6-7-387-392.
About the authors:
Tatiana E. Tyulkova — Dr. Sc. (Med.), Head of the Department of Scientific Research Coordination, National Medical Research Center of Phtysiopulmonology; 4, bldn. 2, Dostoevsky str., Moscow, 127473, Russian Federation; ORCID iD 0000-0002-2292-1228.
Tatiana K. Lugovkina — Dr. Sc. (Med.), Leading Researcher of the Department of Clinical Science, Ural Scientific Research Institute of Phtysiopulmonology — Branch of the National Medical Research Center of Phtysiopulmonology; 50, 22nd Parts’ezd str., Yekaterinburg, 620039, Russian Federation; ORCID iD 0000-0003-2088-8150.
Darya M. Kutuzova — Junior Researcher of the Department of Differential Diagnosis and Treatment of Tuberculosis and Concurrent Diseases, National Medical Research Center of Phtysiopulmonology; 4, bldn. 2, Dostoevsky str., Moscow, 127473, Russian Federation; ORCID iD 0000-0002-4924-9590.
Nelly F. Khabibullina — C. Sc. (Med.), Senior Researcher of the Translational Genomics Laboratory, National Medical Research Center of Phtysiopulmonology; 4, bldn. 2, Dostoevsky str., Moscow, 127473, Russian Federation; ORCID iD 0000-0001-7319-1272.
Contact information: Tatiana E. Tyulkova, e-mail: tulkova@urniif.ru.
Financial Disclosure: no authors have a financial or property interest in any material or method mentioned.
There is no conflict of interests.
Received 13.07.2022.
Revised 05.08.2022.
Accepted 30.08.2022.
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