The relationship between non-alcoholic fatty liver disease and type 2 diabetes mellitus
Sharonova L.A., Verbovoy A.F., Verbovaya N.I., Pashentseva A.V.

Samara State Medical University

In clinical practice, type 2 diabetes mellitus (DM) is often combined with non-alcoholic fatty liver disease (NAFLD). According to the modern concepts, NAFLD is the main component of the metabolic syndrome and the main risk factor for cardiovascular disease. This review discusses current aspects of the pathogenesis of non-alcoholic fatty liver disease, its relationship with type 2 diabetes and obesity, and association with a high risk of cardiovascular disease. Data on the clinical picture and instrumental methods of diagnosis of NAFLD are presented. The possibility of using essential phospholipids in the treatment of NAFLD is considered as an effective, available and pathogenetically substantiated method of therapy. The article demonstrates the effectiveness of the essential phospholipids therapy in improving the laboratory and ultrasound picture of the liver, reducing insulin resistance, systemic and tissue inflammation, and the activity of fibrogenesis in the liver. It is shown that the treatment of NAFLD in patients with type 2 diabetes should start as early as possible, even at the stage of steatosis, in this case one can expect the greatest effect from the therapy used. 

Key words: type 2 diabetes, non-alcoholic fatty liver disease, pathogenesis, insulin resistance, fat function, diagnostics, essential phospholipids.
For citation: Sharonova L.A., Verbovoy A.F., Verbovaya N.I., Pashentseva A.V. The relationship between non-alcoholic fatty liver disease and type 2 diabetes mellitus // RMJ. 2017. № 22. P. 1635–1640.