Extra-osseous effects of vitamin D (a review)
Dreval' A.V., Kryukova I.V., Barsukov I.A., Tevosyan L.Kh.

M.F. Vladimirskiy Moscow Regional Research and Clinical Institute, Moscow

In the last decades, a myriad of comprehensive clinical studies on vitamin D effects were performed worldwide. Many of these studies illustrate the role of vitamin D in reducing the risk of various disorders. Population epidemiological studies demonstrated high rate of vitamin D deficiency in various age groups of certain countries. Early diagnosis and treatment of vitamin D deficiency may reduce the risk of many disorders. At present, we are familiar with the physiology, metabolism, and bone effects of vitamin D as well as its impact on human organs and systems. According to several authors, vitamin D affects ageing, tumorigenesis, atherosclerosis, immune responses, and gene expression.
The paper summarizes the results of clinical studies on vitamin D levels in the population and the influence of obesity on vitamin D levels. Pathogenic role of vitamin D deficiency in cardiovascular and carbohydrate metabolism disorders is illustrated. The results of summarized clinical studies give an idea of protective role of vitamin D in various conditions.

Key words: vitamin D, vitamin D deficiency, 1,25(OH)2D3, 25(OH)D, calcium, vitamin D receptors, cholecalciferol, calcitriol, parathyroid hormone.

For citation: Dreval' A.V., Kryukova I.V., Barsukov I.A., Tevosyan L.Kh. Extra-osseous effects of vitamin D (a review) // RMJ. 2017. № 1. P. 53–56.