Role of testosterone replacement therapy in type 2 diabetes mellitus

T.Yu. Demidova, D.V. Skuridina

Pirogov Russian National Research Medical University, Moscow

As the large-scale Russian epidemiological study NATION has shown, the actual number of patients with type 2 diabetes mellitus (DM2) in Russia is at least 8–9 million people (about 6% of the population). Hypogonadism in men is a clinical and biochemical syndrome associated with a low level of testosterone, as well as insensitivity of the receptor apparatus to androgens. It was shown that testosterone levels in men with DM2 are lower than in healthy people by an average of 2.5 nmol/L, and the prevalence of hypogonadism DM2 patients is higher than in the general population by 50%. Therefore, it is now recommended for all patients with DM2 and obesity to determine the level of testosterone and to decide on the appointment of testosterone replacement therapy (TRT), one of the modern representatives of which is gel Androgel. Since testosterone takes an active part in the regulation of fat and carbohydrate metabolism, the question of improving the parameters of carbohydrate and fat metabolism against the background of TRT in men with DM2 and confirmed hypogonadism remains topical.

Key words: type 2 diabetes, testosterone, substitution therapy, metabolic syndrome, insulin resistance, Androgel.
For citation: Demidova T.Yu., Skuridina D.V. Role of testosterone replacement therapy in type 2 diabetes mellitus // RMJ. 2018. № 11(II). P. 110–115.