Obesity and insulin resistance: pathogenesis and ways of correction

Obesity and insulin resistance: pathogenesis and ways of correction

I.A. Barsukov, A.A. Demina

M.F. Vladimirskiy Moscow Regional Research and Clinical Institute, Moscow

Obesity is currently one of the major healthcare problems. Pathologies associated with obesity (insulin resistance, type 2 diabetes mellitus and cardiovascular diseases) have a significant impact not only on the patient but also on the healthcare system and society as a whole. Insulin resistance is the main pathogenetic mechanism for the development of type 2 diabetes mellitus and many other diseases that significantly affect society. Thus, it is extremely important to understand this condition pathogenesis. The article describes the primary risk factors and mechanisms for the development of insulin resistance: molecular mechanisms, inflammation, endoplasmic reticulum stress, mitochondrial dysfunction. The article also considers the main therapeutic principles concerning correction of this condition, including new drug classes. The accumulation of clinical experience and further research data will help to determine a more precise place of the new drug class in the treatment algorithms for carbohydrate metab olism disorders.

Keywords: diabetes mellitus, obesity, insulin resistance, molecular mechanisms, endoplasmic reticulum stress, mitochondrial dysfunction.

For citation: Barsukov I.A., Demina A.A. Obesity and insulin resistance: pathogenesis and ways of correction. RMJ. 2021;2:26–30.