Metabolic syndrome and cognitive disorders

E.E. Vasenina, O.A. Gankina

Russian Medical Academy of Continuous Professional Education, Moscow

Metabolic syndrome (MS) is an extremely urgent problem of modern society, the MS prevalence is steadily increasing. Recent studies demonstrate the association between MS and cognitive disorders. However, the effect of its various components (obesity, dyslipidemia, insulin resistance and impaired glucose tolerance, hypertension) is not always unambiguous. Some studies demonstrate the "protective" role of overweight, while others call obesity one of the risk factors for the development of cognitive impairment, on the contrary. Data concerning the hypertension effect on the memory disorders and other cognitive impairments are also variable. Besides, it is important to note the mutual impact of various MS components on each other and the possible enhancement of their negative effects when acting together. The article provides an overview of current research concerning the MS effect, its components and combinations on the cognitive impairment manifestation, as well as on the risk of further development of both vascular dementia and Alzheimer’s disease.

Keywords: metabolic syndrome, senile age, cognitive impairment, diabetes mellitus, Alzheimer’s disease, idebenone.

For citation: Vasenina E.E., Gankina O.A. Metabolic syndrome and cognitive disorders. RMJ. 2024;5:12–18.