DOI: 10.32364/2618-8430-2026-9-1-6
A.R. Miyanova1, Yu.A. Dmitrieva1,2, I.G. Kolomina2, I.V. Strunkina2, S.S. Bukin2, I.N. Zakharova1, I.M. Osmanov2
1Russian Medical Academy of Continuous Professional Education, Moscow, Russian Federation
2Z.A. Bashlyaeva Children's City Clinical Hospital, Moscow, Russian Federation
Background: the association between celiac disease (CD) and type 1 diabetes mellitus (DM1) is well-documented, with CD prevalence in this population potentially reaching 16%. Given the frequently paucisymptomatic presentation of CD in children with DM1, systematic serological screening for tissue transglutaminase IgA antibodies (tTG-IgA) is essential for early diagnosis and the prevention of complications.
Aim: to evaluate the effectiveness of CD serological screening in children diagnosed with DM1.
Materials and Methods: screening was conducted in 1,372 children with DM1 (ages 0–17 years). Elevated tTG-IgA levels were detected in 80 (5.84%) patients. Diagnosis was confirmed via endoscopic and histopathological examination of the duodenal mucosa; atrophic enteropathy (Marsh stage 2–3) served as the confirmatory criterion.
Results: CD was verified in 48 patients (3.6% of the total cohort). The median age of DM1 onset was significantly lower in children with confirmed CD compared to those with isolated DM1 (6.5 versus 8.0 years, respectively; p=0.012).
Conclusion: the majority of CD cases were diagnosed within the first five years following DM1 onset, with a five-year cumulative risk of 1.6%. Early-onset DM1 is a significant predictor for increased risk of CD development.
Keywords: Kaplan — Meier survival analysis, tissue transglutaminase IgA antibodies, autoimmune diseases, children, comorbidity, type 1 diabetes mellitus, screening, celiac disease.
For citation: Miyanova A.R., Dmitrieva Yu.A., Kolomina I.G., Strunkina I.V., Bukin S.S., Zakharova I.N., Osmanov I.M. Diagnostic screening for celiac disease in patients with type 1 diabetes mellitus. Russian Journal of Woman and Child Health. 2026;9(1):44–49 (in Russ.). DOI: 10.32364/2618-8430-2026-9-1-6
About the authors:
Aliya R. Miyanova — pediatrician, gastroenterologist, postgraduate student of the G.N. Speransky Department of Pediatrics, Russian Medical Academy of Continuous Professional Education; 2/1 build. 1, Barrikadnaya str., Moscow, 125993, Russian Federation; ORCID iD 0009-0006-3184-1701
Yulia A. Dmitrieva — C. Sc. (Med), Head of the Celiac Disease Treatment Center, gastroenterologist at Z.A. Bashlyaeva Children's City Clinical Hospital; 28, Geroev Panfilovtsev str., Moscow, 125373, Russian Federation; Associate Professor of the G.N. Speransky Department of Pediatrics, Russian Medical Academy of Continuous Professional Education; 2/1 build. 1, Barrikadnaya str., Moscow, 125993, Russian Federation; ORCID iD 0000-0003-0668-7336
Irina G. Kolomina — Head of the Endocrinology Department, Z.A. Bashlyaeva Children's City Clinical Hospital; 28, Geroev Panfilovtsev str., Moscow, 125373, Russian Federation; ORCID iD 0009-0009-0473-1621
Irina V. Strunkina — endocrinologist of the Outpatient Department, Z.A. Bashlyaeva Children's City Clinical Hospital; 28, Geroev Panfilovtsev str., Moscow, 125373, Russian Federation.
Sergey S. Bukin — endocrinologist of the Endocrinology Department, Z.A. Bashlyaeva Children's City Clinical Hospital; 28, Geroev Panfilovtsev str., Moscow, 125373, Russian Federation; ORCID iD 0000-0003-1775-8582
Irina N. Zakharova — Dr. Sc. (Med.), Professor, Head of the G.N. Speransky Department of Pediatrics, Russian Medical Academy of Continuous Professional Education; 2/1 build. 1, Barrikadnaya str., Moscow, 125993, Russian Federation; ORCID iD 0000-0003-4200-4598
Ismail M. Osmanov — Dr. Sc. (Med.), Professor, Head of Z.A. Bashlyaeva Children's City Clinical Hospital; 28, Geroev Panfilovtsev str., Moscow, 125373, Russian Federation; ORCID iD 0000-0003-3181-9601
Contact information: Aliya R. Miyanova, e-mail: miyanova@yandex.ru
Financial Disclosure: no authors have a financial or property interest in any material or method mentioned.
There is no conflict of interest.
Received 10.12.2025.
Revised 13.01.2026.
Accepted 30.01.2026.
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