Collagen therapy opportunites for rehabilitation after plastic surgery
DOI: 10.32364/2587-6821-2025-9-6-10
О.B. Borzykh1, М.М. Petrova2, N.А. Schnayder2,3, S.V. Danilova4
1Artis LLC, Voronezh, Russian Federation
2Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk, Russian Federation
3V.M. Bekhterev National Medical Research Center for Psychiatry and Neurology, St. Petersburg, Russian Federation
4Parallelepiped LLC, Moscow, Russian Federation
Hypertrophic scars are a specific issue reported after plastic surgery. Collagen therapy is one of promising methods to control a wound and to improve its reparation. Clinical efficacy of a medical device based on native type I collagen has been already demonstrated in an ischemic wound animalmodel. Acting as a natural substrate for cell attachment, collagen can mediate a great number of physiological interactions (from angiogenesis to re-epithelialization) that promote regeneration during a complex process of wound healing, The paper demonstrates 2 clinical case studies related to the medical device based on native type I collagen used to control and to improve healing of a post-traumatic and a post-operative wounds. The first patient showed accelerated wound healing resulted in a normotrophic negligible scar. Along with this, controlled and improved healing of a hypertrophic scar was reported in the patient with a post-operative wound. Therefore, this demonstrates efficacy of the medical device based on native type I collagen.
Keywords: wound healing, hypertrophic scar, collagen, collagen therapy, regeneration control.
For citation: Borzykh О.B., Petrova М.М., Schnayder N.А., Danilova S.V. Collagen therapy opportunites for rehabilitation after plastic surgery. Russian Medical Inquiry. 2025;9(6):357–362 (in Russ.). DOI: 10.32364/2587-6821-2025-9-6-10
About the authors:
Olga B. Borzykh — D. Sc. (Med.), Dermatologist, Cosmetologist, Artis LLC; 87, Proletarskaya str., Voronezh, 394030, Russian Federation; ORCID iD 0000-0002-3651-4703
Marina M. Petrova — D. Sc. (Med.), Professor, Head of the Department of Outpatient Therapy and General Practice with a PE course, Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University; 1, Partizan Zheleznyak str., Krasnoyarsk, 660022, Russian Federation; ORCID iD 0000-0002-8493-0058
Natalia A. Sсhnayder — D. Sc. (Med.), Professor, Chief Researcher, Deputy Head of the Institute of Personalized Psychiatry and Neurology, V.M. Bekhterev National Medical Research Center for Psychiatry and Neurology; 3, Bekhterev str., St. Petersburg, 192019, Russian Federation; Leading Researcher of the Center of Collective Usage "Molecular and Cellular Technologies", Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University; 1, Partizan Zheleznyak str., Krasnoyarsk, 660022, Russian Federation; ORCID iD 0000-0002-2840-837X
Svetlana V. Danilova — C. Sc. (Med.), Dermatologist, Cosmetologist, Physiotherapist, Parallelepiped LLC; 6, Yakimansky lane, Moscow, 119049, Russian Federation; ORCID iD 0009-0001-4549-7749
Contact information: Olga B. Borzykh, e-mail: kurumchina@mail.ru
Financial Disclosure: no authors have a financial or property interest in any material or method mentioned.
There is no conflict of interest.
Received 10.03.2025.
Revised 02.04.2025.
Accepted 25.04.2025.
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