Success factors for therapy of various skin disorders in physician’s practice

O.I. Pikuza¹, A.M. Zakirov², A.V. Pikuza¹, A.M. Zakirova¹, M.L. Maksimov^3,4

¹Kazan State Medical University, Kazan

²City Clnical Hospital No. 7, Kazan

³Kazan State Medical Academy, the branch of the Russian Medical Academy of Continuous Professional Education, Kazan

⁴Pirogov Russian National Research Medical University, Moscow

Aim: to study the efficacy and safety of the following: combined topical antibacterial drug containing neomycin and bacitracin for wound detersion from pus and necrotic tissues; reparative processes course; the velocity of wound healing in the treatment of the skin and soft tissue infections.

Patients and Methods: the study involved 105 patients aged 16–77 years with various nosological forms of inflammatory lesions in the soft tissues. These patients were divided into 2 groups: 57 patients (the main group) were prescribed with various combined antibacterial drug forms containing neomycin and bacitracin (Baneocin^®) (powder and ointment), which was distantly applied 3 times a day during dressings; 48 patients (the control group) received the traditional therapy.

Results: as a result of the study, there was a positive effect on reparative processesof the combined topical antibacterial drug containing neomycin and bacitracin. In 67.5% of cases, its efficacy was regarded as excellent and in 31.8% as good. The share of patients cured by day 7 in the main group was 77.2%, in the control group — 52.2% (p<0.01). A significant process resolution was revealed (p<0.05) when evaluating individual signs. When analyzing the dynamics of the clinical signs, a statistically significant relief of pain/burning, soft-tissue edema, and topical hyperthermia/hyperemia was revealed in patients of the main group. In patients with a severe infection process during complex treatment, the resolution of the inflammatory process and foci epithelialization was achieved by the 14th day  of therapy (therapy duration with the drug did not exceed 7 days).

Conclusion: given the conducted study, it can be argued about the high clinical efficacy of the combined topical antibiotic containing neomycin and bacitracin in the treatment of infected wounds of various localizations, which makes it possible to recommend this product for widespread use in everyday clinical practice.

Keywords: inflammatory skin and soft tissue lesions, treatment of infected wounds, bacitracin, neomycin, topical combined antibacterial drug.

For citation: Pikuza O.I., Zakirov A.M., Pikuza A.V. et al. Success factors for therapy of various skin disorders in physician’s practice.
RMJ. 2020;2:15–18.