Clinical experience of using systemic isotretinoin in the treatment of severe forms of acne
E.V. Matushevskaya¹, L.A. Antonova^2,3, Yu.I. Matushevskaya⁴, K.S. Petrova<sup>5

1</sup> Institution of Advanced Training, Federal Medical and Biological Agency, Moscow
² Krasnoyarsk Interdistrict Outpatient Department
³ Epilation and Cosmetology Center «Electra» LLC, Krasnoyarsk
⁴ Lyubertsy Dermatovenerologic Clinic, Moscow Region
⁵ Volga Research Medical University, Nizhny Novgorod

For the treatment of medium and severe forms of acne, the prescription of systemic drugs as antibiotics, hormonal drugs, synthetic retinoids is indicated. The article presents data on the effectiveness and safety of systemic isotretinoin (SI) in the practice of a dermatologist in the treatment of acne. Issues of the acne pathogenesis, a formation of the phenotypic heterogeneity of the Cutibacterium acnes bacterium are considered, an exposome analysis and its effect on the severity and persistence of acne is carried out. Recommendations are given on the management of patients with acne, depending on the form and severity of the pathological process using SI based on current domestic and foreign recommendations. Data of the clinical use of the drug Verocutane^® (based on SI) for the treatment of severe forms of acne are presented.
The SI application in the treatment of medium and severe forms of acne is effective and safe and meets the requirements of modern principles of treatment. A new drug Verocutane^® is registered on the Russian pharmaceutical market. The experience of its use in the treatment of patients with acne has demonstrated a high therapeutic efficacy and low risk of serious adverse events. High efficacy, safety, and an optimal pharmacoeconomic index increase patient compliance with acne therapy.

Key words: acne, exposome, synthetic retinoids, systemic therapy, efficacy, safety, isotretinoin, Verocutane^®.
For citation: Matushevskaya E.V., Antonova L.A., Matushevskaya Yu.I., Petrova K.S. Clinical experience of using systemic isotretinoin in the treatment of severe forms of acne // RMJ. 2018. № 8(II). P. –112.