Aplasia cutis congenital: case report

Aplasia cutis congenital: case report

R.V. Saranyuk^1,2, T.A. Gosteva^1,2, P.M. Abezyaeva³ 

¹Kursk Regional Public Organization "Society for Integrative Dermatology", Kursk

²LLC "Center for Medical Examinations and Prophylaxis", Kursk

³Regional Perinatal Center, Kursk

 Aplasia cutis is a developmental anomaly that manifests at birth or immediately after birth as skin defects of varying severity that occasionally involve subcutaneous fat and musculoskeletal structures. The etiology and pathogenesis of aplasia cutis are not fully understood. To date, its development is known to be associated with numerous endogenous and exogenous factors affecting fetal development, i.e., mechanical (intrauterine trauma) and toxic (various substances, including drugs, e.g., methimazole, diclofenac sodium, and valproic acid, and nicotine) exposure. The clinical manifestations are extremely different and vary depending on the area of lesion and affect different skin sites, thereby complicating the clinical diagnostic search. Although in most cases aplasia cutis is an isolated condition, a physician should beware of severe life-threatening hereditary syndromes and associated developmental anomalies. This paper describes a patient with aplasia cutis congenita, its etiology, pathogenesis, clinical presentation, and management.

Keywords: skin aplasia, developmental anomaly, skin erosion, aplasia cutis congenita.

For citation: Saranyuk R.V., Gosteva T.A., Abezyaeva P.M. Aplasia cutis congenital: case report. RMJ. 2023;6:36–38.