DOI: 10.32364/2587-6821-2024-8-11-11
A.E. Shulzhenko, R.V. Shchubelko, I.N. Zuikova
National Research Center Institute of Immunology of the Russian Federal Medical Biological Agency, Moscow, Russian Federation
Due to the widespread prevalence of labial herpes, it constitutes a significant challenge not only for patients, who commonly do not seek medical assistance, but also for healthcare professionals across various specialties — including dermatologists, immunologists, and dentists. These practitioners frequently encounter severe, recurrent manifestations of herpesvirus infections. This review article addresses the issues associated with labial herpes, providing current insights into the pathogenesis and immune response patterns in herpesvirus infection. It also discusses different clinical presentations and potential diagnostic errors. The article delineates primary treatment tactics for herpesvirus infections, emphasizing both etiotropic and immunomodulatory therapeutic approaches. The administration of immunotropic agents should be informed by a detailed understanding of the disease's immunopathogenesis, as well as the capabilities offered by modern immunodiagnostics and immunopharmacology. Furthermore, the article presents case studies involving patients with labial herpes who were treated using a topical gel form of an immunomodulatory phytopharmaceutical. The findings suggest that this dosage form can be effectively utilized as an adjunctive topical therapy for managing recurrences of herpesvirus infections caused by herpes simplex virus type 1.
Keywords: herpes simplex viruses, HSV-1, labial herpes, immunomodulators, topical therapy, polysaccharides of the plant Solanum tuberosum.
For citation: Shulzhenko A.E., Shchubelko R.V., Zuikova I.N. Herpesvirus infections in adults — labial herpes case study. Russian Medical Inquiry. 2024;8(11):674–680 (in Russ.). DOI: 10.32364/2587-6821-2024-8-11-11
About the authors:
Andrey E. Shulzhenko — Dr. Sc. (Med.), Professor, Head of the Department of Allergology No. 6, National Research Center Institute of Immunology of the Russian Federal Medical Biological Agency; 24, Kashirskoye road, Moscow, 115522, Russian Federation; ORCID iD 0000-0003-0268-9350
Rosalia V. Shchubelko — C. Sc. (Med.), allergologist-immunologist, Senior Researcher at the Department of Allergology No. 6, National Research Center Institute of Immunology of the Russian Federal Medical Biological Agency; 24, Kashirskoye road, Moscow, 115522, Russian Federation; ORCID iD 0000-0001-6993-9831
Irina N. Zuikova — C. Sc. (Med.), allergologist-immunologist, Senior Researcher at the Department of Allergology No. 6, National Research Center Institute of Immunology of the Russian Federal Medical Biological Agency; 24, Kashirskoye road, Moscow, 115522, Russian Federation; ORCID iD 0000-0002-9373-4681
Contact information: Irina N. Zuikova, e-mail: zuikova_i@mail.ru
Financial Disclosure: no authors have a financial or property interest in any material or method mentioned.
There is no conflict of interest.
Received 16.09.2024.
Revised 09.10.2024.
Accepted 30.10.2024.
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