Effectiveness of cream with bacteriorhodopsin in patients with psoriasis

O.Yu. Olisova, I.S. Maximov, A.S. Allenova

Sechenov University, Moscow

Psoriasis is a chronic immune-mediated inflammatory skin disease, characterized by a papulosquamous eruption. Effective and safe topical preparations development for mild to moderate psoriasis remains a critical problem. Bacteriorhodopsin, a retinal containing chromoprotein, recently appeared in the cosmetic market and can be used by patients with psoriasis.

Aim: to evaluate efficacy and tolerance of day and night cream with bacteriorhodopsin in patients with psoriasis.

Patients and Methods: the study enrolled 30 patients (19 men and 11 women), aged 18 to 79 years (average age was 43.9±11.5), with mild (27/30) and moderate (3/30) severity vulgar psoriasis. Medication effectiveness study was carried out using confocal laser scanning microscopy in vivo on the 0th and 2nd week, PASI indices determination was carried out on the 0th, 2nd, 4th week, dermatology specific quality of life (DSQL) — on the 0th, 4th week.

Results: 4 weeks after beginning the cream treatment course, there was a significant PASI reduction (average score 6.3±2.6 in week 0 compared to 2.0±1.6 in week 4) (p<0.05). There was a significant improvement in the patient’s life quality: average DSQL in week 0 was 11.9±3.21 compared to 3.9±2.0 in week 4 (p<0.05). In week 4, 86,6% of patients (26/30) achieved clinical improvement with PASI decrease more than 50% (p<0.05). Nine patients achieved a 50% PASI decrease, eight — 75%, five — 90%, four — 100%.

Conclusion: creams with bacteriorhodopsin contribute to the rapid elimination of disease clinical manifestations and improve life quality, which is confirmed by the results of the confocal microscopy and the PASI and DSQL average indices decrease to 68% and 67% respectively.

Keywords: psoriasis, bacteriorhodopsin, retinoids, psoriasis therapy, Restet.

For citation: Olisova O.Yu., Maximov I.S., Allenova A.S. Effectiveness of cream with bacteriorhodopsin in patients with psoriasis. RMJ. 2019;4:54–58.