Dexpanthenol in the treatment of atopic dermatitis in children and adults

1. Kelly G. S. Pantothenic acid. Monograph // Altern Med Rev. 2011. Vol. 16. P.263–274. 2. Lanska D. J. The discovery of niacin, biotin, and pantothenic acid // Ann Nutr Metab. 2012. Vol. 61. P.246–253. 3. Williams R. J., Saunders D. H. The effects of inositol, crystalline vitamin B (1) and «pantothenic acid»; on the growth of different strains of yeast // Biochem J. 1934. Vol. 28. P.1887–1893. 4. Stuttgen G., Krause H. Die percutane absorption von Tritium- € markiertem panthenol bei mensch und tier // Arch Klin Exp Derm. 1960. Vol. 209. P.578–582. 5. Wollina U., Kubicki J. Multiaktive eigenschaften von dexpanthenol-haltigen externa // Kosm Med. 2007. Vol. 2. P.14–18. 6. Abiko Y., Tomikawa M., Shimizu M. Enzymatic conversion of pantothenylalcohol to pantothenic acid // J Vitaminol (Kyoto). 1969. Vol. 15. P.59–69. 7. Proksch E., Jensen J. M., Dexpanthenol. In Barel A. O., Paye M., Maibach H. I., ed. Handbook of Cosmetic Science and Technology. 2nd ed. New York, London: Taylor and Francis Group. 2006. Р.399–406. 8. Proksch E., Holleran W. M., Menon G. K. et al. Barrier function regulates epidermal lipid and DNA synthesis // Br J Dermatol. 1993. Vol. 128. P.473–482. 9. Slyshenkov V. S., Rakowska M., Moiseenok A. G., Wojtczak L. Pantothenic acid and its derivatives protect Ehrlich ascites tumor cells against lipid peroxidation // Free Radic Biol Med. 1995. Vol. 19. P.767–772. 10. Proksch E., Nissen H. P. Dexpanthenol enhances skin barrier repair and reduces inflammation after sodium lauryl sulphate-induced irritation // J Dermatolog Treat. 2002. Vol. 13. P.173–178. 11. Wollina U. Zur klinischen wirksamkeit von dexpanthenol // Kosm Med. 2001. Vol. 4. P.180–184. 12. Hosemann W., Wigand M. E., Gode U. et al. Normal wound € healing of the paranasal sinuses: clinical and experimental investigations. Eur Arch Otorhinolaryngol. 1991. Vol. 248. P.390–394. 13. Hosemann W., Gode U., Wigand M. E., et al. Experimentelle untersuchungen zur wunderheilung in den nasennebenhoh // HNO. 1991. Vol. 39. P.48–54. 14. Weimann B. I., Hermann D. Studies on wound healing: effects of calcium D-pantothenate on the migration, proliferation and protein synthesis of human dermal fibroblasts in culture // Int J Vitam Nutr Res. 1999. Vol. 69. P.113–119. 15. Wollina U., Kubicki J. Dexpanthenol supports healing of superficial wounds and injuries // Kosm Med. 2006. Vol. 27. P.240–249. 16. Marquardt Y., Amann P. M., Heise R. et al. Characterization of a novel standardized human three-dimensional skin wound healing model using non-sequential fractional ultrapulsed CO2 laser treatments // Lasers Surg Med. 2015. Vol. 47. P.257–265. 17. Oguz A., Uslukaya O., Alabalk U. et al. Topical N-acetylcysteine improves wound healing comparable to dexpanthenol: an experimental study // Int Surg. 2015. Vol. 100. P.656–661. 18. Danby S. G. Biological variation in skin barrier function: from A (atopic dermatitis) to X (xerosis) // Curr Probl Dermatol. 2016. Vol. 49. P.47–60. 19. Gimenez-Arnau A. Standards for the protection of skin barrier function // Curr Probl Dermatol. 2016. Vol. 49. P.123–134. 20. Loden M. Treatments improving skin barrier function. Curr Probl Dermatol 2016. Vol. 49. P.112–122. 21. Bjorklund S., Pham Q. D., Jensen L. B. et al. The effects of polar € excipients transcutol and dexpanthenol on molecular mobility, permeability, and electrical impedance of the skin barrier // J Colloid Interface Sci. 2016. Vol. 479. P.207–220. 22. Proksch E. The role of emollients in the management of diseases with chronic dry skin. Skin Pharmacol Physiol // 2008. Vol. 21. P.75–80. 23. Ring J., Alomar A., Bieber T. et al. Guidelines for treatment of atopic eczema (atopic dermatitis) part I. J Eur Acad Dermatol Venereol. 2012. Vol. 26. P.1045–1060. 24. Simpson E. L., Berry T. M., Brown P. A., Hanifin J. M. A pilot study of emollient therapy for the primary prevention of atopic dermatitis // J Am Acad Dermatol. 2010. Vol. 63. P.587–593. 25. Simpson E. L., Chalmers J. R., Hanifin J. M. et al. Emollient enhancement of the skin barrier from birth offers effective atopic dermatitis prevention // J Allergy Clin Immunol. 2014. Vol. 134. P.818–823. 26. Gelmetti C., Metz M., Proksch E. Expert panel on best practices in atopic dermatitis management: outcome and recommendations // KOM Dermatol. 2015. Vol. 10. P.1–4. 27. Gehring W., Gloor M. Effect of topically applied dexpanthenol on epidermal barrier function and stratum corneum hydration. Results of a human in vivo study // Arzneimittelforschung. 2000. Vol. 50. P.659–663. 6 E. PROKSCH ET AL. 28. Gehring W., Gloor M. Der repetitive waschtest als modell zur beurteilung von hautschutzpraparaten am beispiel einer dexpanthenolhaltigen formulierung // Akt Dermatol. 2001. Vol. 27. P.279–284. 29. Gehring W., Gloor M. Der effekt von dexpanthenol bei experimentell gesch€adigter haut // Z Hautkr. 2001. Vol. 76. P.212–218. 30. Biro K., Thaci D., Ochsendorf F. R. et al. Efficacy of dexpanthenol in skin protection against irritation: a double-blind, placebo-controlled study // Contact Dermatitis. 2003. Vol. 49. P.80–84. 31. Stettler H., Kurka P., Lunau N. et al. A new topical panthenolcontaining emollient: results from two randomized controlled studies assessing its skin moisturization and barrier restoration potential, and the effect on skin microflora // J Dermatolog Treat. 2017. Vol. 28. P.173–180. 32. Stettler H., Kurka P., Wagner C. et al. A new topical panthenol-containing emollient: skin-moisturizing effect following single and prolonged usage in healthy adults, and tolerability in healthy infants // J Dermatolog Treat. 2016. Vol. 22. P.1–7. [Epub ahead of print] 33. Goujon C., Alleaume B., de Bony R., Girard P. Randomized single-blind pilot comparison study of the efficacy and tolerability of BepanthenVR Ointment in subjects with bilateral dryness of the hands. Real Therap Dermatol. 1997. Vol. 66. P.47–33. 34. Camargo F. B. Jr, Gaspar L. R., Maia Campos P. M. Skin moisturizing effects of panthenol-based formulations // J Cosmet Sci. 2011. Vol. 62. P.361–370.